RNA Interference

Challenges and Therapeutic Opportunities

  • Mouldy Sioud

Part of the Methods in Molecular Biology book series (MIMB, volume 1218)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Yuko Nakashima, Naoko Abe, Yoshihiro Ito, Hiroshi Abe
    Pages 17-36
  3. Giuseppe De Rosa, Giuseppina Salzano
    Pages 43-51
  4. Olga Mykhaylyk, Yolanda Sanchez-Antequera, Dialechti Vlaskou, Maria Belen Cerda, Mehrdad Bokharaei, Edelburga Hammerschmid et al.
    Pages 53-106
  5. Omar Ahmed, Andrea Krühn, Hermann Lage
    Pages 117-129
  6. Karin Zins, Mouldy Sioud, Seyedhossein Aharinejad, Trevor Lucas, Dietmar Abraham
    Pages 143-161
  7. Magdolna G. Sebestyén, So C. Wong, Vladimir Trubetskoy, David L. Lewis, Christine I. Wooddell
    Pages 163-186
  8. William H. Thiel, Kristina W. Thiel, Katie S. Flenker, Tom Bair, Adam J. Dupuy, James O. McNamara II et al.
    Pages 187-199
  9. Maximilian C. R. Buff, Stefan Bernhardt, Musa D. Marimani, Abdullah Ely, Joachim W. Engels, Patrick Arbuthnot
    Pages 217-249
  10. Mouldy Sioud, Anne Mobergslien, Stein Sæbøe-Larssen
    Pages 269-276
  11. Jia Han Deng, Peter Deng, Shi-Lung Lin, Shao-Yao Ying
    Pages 321-340
  12. Andrew Schuster, Grant W. Hennig, Nicole Ortogero, Dickson Luong, Wei Yan
    Pages 341-351
  13. Nicole Ortogero, Grant W. Hennig, Dickson Luong, Wei Yan
    Pages 353-364
  14. Sebastian Vencken, Tidi Hassan, Noel G. McElvaney, Stephen G. J. Smith, Catherine M. Greene
    Pages 365-373
  15. Shigeru Takasaki
    Pages 375-413
  16. Valentina Profumo, Valentina Doldi, Paolo Gandellini, Nadia Zaffaroni
    Pages 415-437
  17. Hana Mlcochova, Renata Hezova, Albano C. Meli, Ondrej Slaby
    Pages 439-463
  18. Morten P. Oksvold, Axl Neurauter, Ketil W. Pedersen
    Pages 465-481
  19. Back Matter
    Pages 491-495

About this book


RNA Interference: Challenges and Therapeutic Opportunities provides readers with recent advances in siRNA design, delivery, targeting, and methods to minimize siRNA’s unwanted effects. Preclinical and clinical use of synthetic siRNAs, the roles of miRNAs in cancer, and the promise of extracellular miRNAs for diagnosis are also covered in this meticulous collection, along with novel methods for identifying endogenous siRNAs and the annotation of small RNA transcriptomes. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.


Comprehensive and cutting-edge, RNA Interference: Challenges and Therapeutic Opportunities will aid researchers, clinicians, teachers, and biotechnologists interested in the power of RNA-based therapies.


Cancer research Extracellular miRNAs Off-target effects RNAi gene silencing Small RNA transcriptomes Small interfering RNAs Synthetic siRNAs siRNA design & delivery

Editors and affiliations

  • Mouldy Sioud
    • 1
  1. 1.Institute for Cancer Research, Oslo University HospitalMontebelloNorway

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2015
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-1537-8
  • Online ISBN 978-1-4939-1538-5
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site