Technical Aspects of Toxicological Immunohistochemistry

System Specific Biomarkers

  • Syed A. Aziz
  • Rekha Mehta

Table of contents

  1. Front Matter
    Pages i-xi
  2. Ana Mendes-da-Silva, Filomena Adega, Raquel Chaves
    Pages 21-49
  3. Daniel G. Cyr, Patrick J. Devine, Isabelle Plante
    Pages 113-145
  4. Ahmad Nazrun Shuid, Isa Naina Mohamed, Norliza Muhammad, Elvy Suhana Mohd Ramli, Norazlina Mohamed
    Pages 193-213
  5. Nivaldo A. Parizotto, Natalia C. Rodrigues, Paulo Sergio Bossini, Michael R. Hamblin
    Pages 215-226
  6. Back Matter
    Pages 227-231

About this book


This volume examines immunohistochemical methods for investigating the toxicologic pathology of rodent and other animal tissues. Eleven comprehensive chapters provide pathologists and researchers in various sub-disciplines of toxicology with an authoritative review of the methods of immunohistochemical staining in various target tissues. Further, this book explores the tissue-, antigen-, and antibody-specific problems that may be encountered during the staining procedures and provides potential avenues for resolving various methodological issues. Special attention is paid to the latest enhancement procedures for antigen retrieval and visualization as well as to image analysis and antigen quantification. Written by leading researchers in toxicology and pathology, this book is a significant resource for toxicologists and pathologists working with rodents and other animal models. The information in Technical Aspects of Toxicological Immunohistochemistry is rounded out by the companion book, Toxicological Immunohistochemistry which examines mechanistic and predictive biomarkers for toxicological evaluation. 


cell biology diagnostic pathology immunocytochemistry tissue biology toxicologic pathology tumor diagnosis

Editors and affiliations

  • Syed A. Aziz
    • 1
  • Rekha Mehta
    • 2
  1. 1.Health Products and Food Branch Health CanadaRegulatory Toxicology Research Division Food DirectorateOttawaCanada
  2. 2.Health Products and Food Branch Health CanadaRegulatory Toxicology Research Division Food DirectorateOttawaCanada

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2016
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4939-1515-6
  • Online ISBN 978-1-4939-1516-3
  • About this book