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Table of contents

  1. Front Matter
    Pages i-ix
  2. Adam C. Errington
    Pages 1-14
  3. Jean-Marc Fritschy, Patrizia Panzanelli
    Pages 15-32
  4. Robert L. Macdonald, Emmanuel J. Botzolakis
    Pages 33-50
  5. William M. Connelly
    Pages 75-84
  6. Damian Bright, Catriona Houston, Stephen Brickley
    Pages 85-124
  7. William M. Connelly, Adam C. Errington, Josue G. Yagüe, Anna Cavaccini, Vincenzo Crunelli, Giuseppe Di Giovanni
    Pages 125-153
  8. Emanuel Loeza-Alcocer, Carmen Andrés, Justo Aguilar, Ricardo Felix, Rodolfo Delgado-Lezama
    Pages 155-178
  9. Andrew N. Clarkson, Mary Chebib
    Pages 179-205
  10. Matthew C. Walker, Ivan Pavlov
    Pages 207-221
  11. Vincenzo Crunelli, Giuseppe Di Giovanni, H. Rheinallt Parri, Adam C. Errington
    Pages 223-237
  12. Back Matter
    Pages 285-295

About this book

Introduction

GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.

Keywords

GABAA tonic inhibition Parkinson's disease alcohol addiction epilepsy

Editors and affiliations

  • Adam C. Errington
    • 1
  • Giuseppe Di Giovanni
    • 2
  • Vincenzo Crunelli
    • 3
  1. 1.Neuroscience and Mental Health Research Institute, Institute of Psychological Medicine and Clinical Neuroscience, School of MedicineCardiff UniversityCardiffUnited Kingdom
  2. 2.Dept. of Physiology & BiochemistryUniversity of MaltaMsida MSDMalta
  3. 3.School of BiosciencesCardiff UniversityCardiffUnited Kingdom

Bibliographic information