Subunit Vaccine Delivery

  • Camilla Foged
  • Thomas Rades
  • Yvonne Perrie
  • Sarah Hook

Part of the Advances in Delivery Science and Technology book series (ADST)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Background

    1. Front Matter
      Pages 1-1
    2. Andrew J. Highton, Roslyn A. Kemp
      Pages 3-14
    3. Rie S. Kallerup, Camilla Foged
      Pages 15-29
  3. Delivery Systems for Subunit Vaccines

    1. Front Matter
      Pages 31-31
    2. Ruchi R. Shah, Luis A. Brito, Derek T. O’Hagan, Mansoor M. Amiji
      Pages 59-76
    3. Elisabeth Kastner, Signe T. Schmidt, Alexander Wilkinson, Dennis Christensen, Yvonne Perrie
      Pages 77-94
    4. Hanne M. Nielsen, Henriette B. Hübschmann, Thomas Rades
      Pages 141-158
    5. Braeden Donaldson, Farah Al-Barwani, Vivienne Young, Sarah Scullion, Vernon Ward, Sarah Young
      Pages 159-180
    6. Thomas Schuster, Martin Nussbaumer, Patric Baumann, Nico Bruns, Wolfgang Meier, Anja Car
      Pages 181-201
    7. Sarah Gordon
      Pages 203-220
    8. Olivier Gasser, Ian F. Hermans
      Pages 243-257
  4. Delivery Routes, Devices and Dosage Forms

    1. Front Matter
      Pages 259-259
    2. Pål Johansen, Thomas M. Kündig
      Pages 261-286
    3. Regina Scherließ
      Pages 287-306
    4. Wouter F. Tonnis, Anke L. W. Huckriede, Wouter L. J. Hinrichs, Henderik W. Frijlink
      Pages 307-329
    5. Deborah Lowry
      Pages 331-346
    6. Teerawan Rattanapak, Camilla Foged, Sarah Hook
      Pages 347-369
  5. Pharmaceutical Analysis and Quality Control of Vaccines

    1. Front Matter
      Pages 371-371
    2. Yuan Cheng, Justin C. Thomas, Sangeeta B. Joshi, David B. Volkin, C. Russell Middaugh
      Pages 385-412
    3. Mette Hamborg, Camilla Foged
      Pages 413-426
  6. Back Matter
    Pages 427-431

About this book


This comprehensive volume compiles the concepts essential for the understanding of the pharmaceutical science and technology associated with the delivery of subunit vaccines. Twenty-one chapters are divided into four main parts: (I) Background; (2) Delivery Systems for Subunit Vaccines; (3) Delivery Routes, Devices and Dosage Forms; and (4) Pharmaceutical Analysis and Quality Control of Vaccines. Part one provide a basic background with respect to immunology and general vaccine classification. In part two, it presents representative types of vaccine delivery systems individually with focus on the physicochemical properties of the systems and their significance for the immune response they stimulate. These delivery systems include aluminum adjuvants, emulsions, liposomes, bilosomes, cubosomes/hexosomes, ISCOMs, virus-like particles, polymeric nano- and microparticles, gels, implants and cell-based delivery systems.


Following these chapters, part three addresses the challenges associated with vaccine delivery via specific routes of administration—in particular subcutaneous, intramuscular, oral, nasal, pulmonary, transdermal and vaginal administration. Furthermore, the specific administration routes are discussed in combination with device technologies relevant for the respective routes as well as dosage forms appropriate for the device technology. Finally, the fourth part concerns pharmaceutical analysis and quality control of subunit vaccines.


adjuvants antigens immunity liposomes recombinant proteins vaccines

Editors and affiliations

  • Camilla Foged
    • 1
  • Thomas Rades
    • 2
  • Yvonne Perrie
    • 3
  • Sarah Hook
    • 4
  1. 1.Department of PharmacyUniversity of Copenhagen, Faculty of Health and Medical SciencesCopenhagenDenmark
  2. 2.University of CopenhagenCopenhagenDenmark
  3. 3.Pharmacy SchoolAston University, School of Life and Health SciencesBirminghamUnited Kingdom
  4. 4.Division of Health SciencesUniversity of Otago, School of PharmacyDunedinNew Zealand

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2015
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4939-1416-6
  • Online ISBN 978-1-4939-1417-3
  • Series Print ISSN 2192-6204
  • Series Online ISSN 2192-6212
  • Buy this book on publisher's site