Management of Castration Resistant Prostate Cancer

  • Fred Saad
  • Mario A. Eisenberger

Part of the Current Clinical Urology book series (CCU)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Castrate-Resistant Prostate Cancer: Clinical and Biological Considerations

    1. Front Matter
      Pages 1-1
    2. William G. Nelson, Kenneth J. Pienta
      Pages 31-41
    3. Steve Y. Cho, Seyed S. Dianat, Katarzyna J. Macura
      Pages 43-63
  3. Treatment: The Androgen Receptor Signaling Axis Biology and Therapeutic Opportunities, Systemic Chemotherapy, Immunotherapy, Bone Targeted Approaches and Radiopharmaceuticals

    1. Front Matter
      Pages 65-65
    2. Heather H. Cheng, Bruce Montgomery
      Pages 67-75
    3. Jarett L. Feldman, Dana Rathkopf, Michael J. Morris
      Pages 77-94
    4. Adam Siegel, Charles J. Ryan
      Pages 95-105
    5. Robert J. van Soest, Ellen S. de Morrée, Cora N. Sternberg, Ronald de Wit
      Pages 107-119
    6. Romualdo Barroso-Sousa, Charles G. Drake
      Pages 121-137
    7. Benjamin A. Gartrell, Fred Saad
      Pages 139-153
    8. Oliver Sartor, Brian Lewis
      Pages 155-163
  4. New Drug Development: Clinical Trials Design in CRPC

    1. Front Matter
      Pages 165-165
    2. Aurelius Omlin, Carmel Pezaro, Johann S. de Bono
      Pages 167-176
    3. Carmel Pezaro, Aurelius Omlin, Johann S. de Bono
      Pages 177-186
    4. Jorge A. Garcia, Robert Dreicer
      Pages 187-199
  5. New Drug Development: Specific Targets

    1. Front Matter
      Pages 201-201
    2. Daniel J. George, William Kelly, Aaron Mitchell
      Pages 203-231
    3. Amina Zoubeidi, Martin Gleave
      Pages 233-248
    4. Hans J. Hammers, Emmanuel S. Antonarakis
      Pages 249-252
    5. Joaquin Mateo, Timothy A. Yap, Johann S. De Bono
      Pages 253-264
    6. Petros D. Grivas, David C. Smith
      Pages 265-276
    7. Leigh Ellis, Sheng-Yu Ku, Elena Lasorsa, Roberto Pili
      Pages 277-295
    8. Himisha Beltran, Gurveen Kaur, Myriam Kossai, David M. Nanus, Scott T. Tagawa
      Pages 297-304
  6. Clinical Management Aspects

  7. Back Matter
    Pages 329-337

About this book


This volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC. The book features an in-depth review of proven therapeutic options, including bone-targeted therapies, immunotherapy, chemotherapy and hormonal based therapies. Combination therapy as well as novel targeted approaches presently under investigation are also reviewed. The text provides up-to-date guidelines and algorithms for the management of CRPC based on international guidelines presently available as well as evidence-based medicine.

As a concise yet comprehensive summary of the current status of the field, Management of Castration Resistant Prostate Cancer serves as a very useful resource for physicians and researchers dealing with this challenging malignancy.


Prostate Cancer Urology androgen receptor immunotherapy radiopharmaceuticals

Editors and affiliations

  • Fred Saad
    • 1
  • Mario A. Eisenberger
    • 2
  1. 1.Department of SurgeryUniversity of Montreal Hospital CenterMontrealCanada
  2. 2.Department of OncologyThe Johns Hopkins UniversityBaltimoreUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2014
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-1-4939-1175-2
  • Online ISBN 978-1-4939-1176-9
  • Series Print ISSN 2197-7194
  • Series Online ISSN 2197-7208
  • Buy this book on publisher's site