Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders

  • Maurizio Popoli
  • David Diamond
  • Gerard Sanacora

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Bruce S. McEwen
    Pages 1-18
  3. Marian Joëls, Harm Krugers, Henk Karst
    Pages 19-32
  4. Laura Musazzi, Giulia Treccani, Carla Perego, Nicoletta Nava, Jens R Nyengaard, Maurizio Popoli
    Pages 33-52
  5. J.Megan Gray, Haley A. Vecchiarelli, Matthew N. Hill
    Pages 99-124
  6. Jaideep S. Bains
    Pages 125-136
  7. Menahem Segal, Nicola Maggio
    Pages 137-150
  8. Jeansok J. Kim, Blake A. Pellman, Eun Joo Kim
    Pages 151-165
  9. George E. Farmer, Collin R. Park, Laura A. Bullard, David M. Diamond
    Pages 167-182
  10. Beverly French, Marianne L. Seney, Etienne Sibille
    Pages 223-244
  11. J.C. Hammond, D. Shan, J.H. Meador-Woodruff, R.E. McCullumsmith
    Pages 265-294
  12. Claudia A. Grillo, Lawrence P. Reagan
    Pages 295-311
  13. Back Matter
    Pages 343-355

About this book


An overview of the ways in which stress affects brain function or synaptic plasticity and can precipitate the onset of neuropsychiatric disorders. Recent research has shown that changes in glutamate/GABA synapses and related pathways are involved in determining whether the effects of a particular stressor will be adaptive or maladaptive. Among the topics discussed are the impact of behavioral stress and glucocorticoids on tripartite glutamate synapses and synaptic transmission, the way that psychiatric drugs affect these same mechanisms, and how the molecular/cellular/functional effects of stress may trigger disorders such as depression, schizophrenia, anxiety, and PTSD. The results presented have been obtained through a range of different and complementary methods including live imaging, electrophysiology, glutamate release from isolated live synaptic terminals, transgenic and animal models, and new behavioral methods.


glutamate mood/anxiety disorders stress synaptic plasticity synaptic transmission

Editors and affiliations

  • Maurizio Popoli
    • 1
  • David Diamond
    • 2
  • Gerard Sanacora
    • 3
  1. 1.Department of Pharmacological and Biomolecular SciencesUniversity of MilanoMilanoItaly
  2. 2.Department of PsychologyUniversity of South FloridaTampaUSA
  3. 3.Psychiatry Depression Research ProgramYale School of MedicineNew HavenUSA

Bibliographic information