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Mitochondrial Function in Lung Health and Disease

  • Viswanathan Natarajan
  • Narasimham L. Parinandi

Part of the Respiratory Medicine book series (RM, volume 15)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Harijith Anantha, Prasad Kanteti, Panfeng Fu, Sainath R. Kotha, Narasimham L. Parinandi, Viswanathan Natarajan
    Pages 1-25
  3. Narsa M. Reddy, Wajiha Qureshi, Haranath Potteti, Dhananjaya V. Kalvakolanu, Sekhar P. Reddy
    Pages 27-50
  4. Ulaganathan Mabalirajan, Anurag Agrawal, Balaram Ghosh
    Pages 51-70
  5. Ganesh K. Kumar, Gayatri Raghuraman, Nanduri R. Prabhakar
    Pages 71-91
  6. Niccole Schaible, Philippe Delmotte, Gary C. Sieck
    Pages 93-116
  7. Sainath R. Kotha, Travis O. Gurney, Miles U. Magalang, Thomas J. Hund, Abhay R. Satoskar, Peter J. Mohler et al.
    Pages 117-139
  8. Lidza Kalifa, Michael A. O’Reilly
    Pages 141-159
  9. Luis Puente-Maestu, Jorge Chancafe-Morgan
    Pages 161-176
  10. Katherine L. Tuggle, Michelle V. Fanucchi
    Pages 177-214
  11. Back Matter
    Pages 215-222

About this book

Introduction

Mitochondria, often referred to as the “powerhouses” of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis.  Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction.  Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling.  Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma.  

Keywords

Biogenesis Fibrosis Lung health Mitochondria Pulmonary Arterial Hypertension Sepsis

Editors and affiliations

  • Viswanathan Natarajan
    • 1
  • Narasimham L. Parinandi
    • 2
  1. 1.Department of Pharmaology and MedicineUniversity of Illinois at ChicagoChicagoUSA
  2. 2.Division of Allergy, Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, College of MedicineOhio State University Wexner, Medical CenterColumbusUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-0829-5
  • Copyright Information Springer Science+Business Media New York 2014
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Medicine
  • Print ISBN 978-1-4939-0828-8
  • Online ISBN 978-1-4939-0829-5
  • Series Print ISSN 2197-7372
  • Series Online ISSN 2197-7380
  • Buy this book on publisher's site