© 2014

Studies on Pediatric Disorders

  • Hirokazu Tsukahara
  • Kazunari Kaneko

Table of contents

  1. Front Matter
    Pages i-xii
  2. General Topics

    1. Front Matter
      Pages 1-1
    2. Ola Didrik Saugstad
      Pages 3-13
    3. Hideo Yamasaki, Naoko S. Watanabe, Jon Fukuto, Michael F. Cohen
      Pages 35-54
    4. Eisei Noiri, Kousuke Minami
      Pages 55-69
    5. Tayo Katano, Seiji Ito
      Pages 71-84
  3. Basic Science Topics

    1. Front Matter
      Pages 85-85
    2. Tsuyoshi Oikawa, Takeshi Sugaya
      Pages 115-135
    3. Masayuki Kubo, Keiki Ogino
      Pages 149-158
    4. Varadarajan Sudhahar, Tohru Fukai
      Pages 183-209
    5. Toru Yamashita, Koji Abe
      Pages 211-218
    6. Masato Yashiro, Hirokazu Tsukahara, Tsuneo Morishima
      Pages 233-252
  4. Clinical Topics

    1. Front Matter
      Pages 253-253
    2. Akihiro Yachie
      Pages 255-270
    3. Tomoyo Yahata, Kenji Hamaoka
      Pages 271-282

About this book


This volume examines the role of oxidative stress in the pathology of numerous pediatric disorders. It covers a wide range of topics including the chemistry and biology of reactive oxygen species and nitric oxide, molecular biology of the enzymes generating these species, clinically useful biomarkers for evaluating oxidative stress status in humans, and the pathophysiology, clinical course and management of a variety of pediatric disorders, among others. The book also describes current diagnostic tools, laboratory methods and technology for treatment and prevention of pediatric disorders.  It explores emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents.

Written by an international team of experts in both pediatrics and  free radical and antioxidant research, Studies on Pediatric Disorders is an invaluable addition to the Oxidative Stress in Applied Basic Research and Clinical Practice series.


Antioxidants Biomarkers Free radicals Nitric oxide Oxidative stress Pediatric disorders

Editors and affiliations

  • Hirokazu Tsukahara
    • 1
  • Kazunari Kaneko
    • 2
  1. 1.Dentistry and Pharmaceutical Sciences Department of PediatricsOkayama University Graduate School of MedicineOkayamaJapan
  2. 2.Department of PediatricsKansai Medical UniversityOsakaJapan

About the editors

Hirokazu Tsukahara, MD, PhD graduated from the School of Medicine at Kyoto University, in Kyoto, Japan and obtained his PhD in medical science from Fukui Medical School, in Fukui, Japan. He is currently Associate Professor at the Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences. Dr. Tsukahara is a clinical scientist, specializing in the field of pediatrics and biological responses. He is the author or coauthor of more than 200 scientific papers and book chapters on general pediatrics, neonatology, endocrinology, metabolic diseases, infectious diseases, and cardiovascular diseases. His experimental research is focused on the chemistry and biology of nitric oxide, free radicals, and other bioactive mediators.


Kazunari Kaneko, MD, PhD graduated from the School of Medicine at Niigata University in Niigata, Japan and obtained his PhD in medical science from Juntendo University, in Tokyo. He is currently Professor and Chairman of the Department of Pediatrics at Kansai Medical University, Osaka, Japan. Dr. Kaneko is a pediatric nephrologist and a leading scientist in clinical studies, specializing in nephrotic syndrome and electrolyte disorders. He has also conducted basic research into the pathophysiological roles of nitric oxide and reactive oxygen species in diverse pediatric kidney diseases. He is currently a member of several regional and international societies including: Japan Pediatric Society (Councilor), Pediatric Nephrology (Executive board member), International Pediatric Nephrology Association, International Society of Nephrology, and American Society of Nephrology. He is on the editorial boards of several well-regarded medical journals, including International Journal of Nephrology, Clinical and Experimental Nephrology, and Journal of Pediatric Biochemistry.

Bibliographic information

  • Book Title Studies on Pediatric Disorders
  • Editors Hirokazu Tsukahara
    Kazunari Kaneko
  • Series Title Oxidative Stress in Applied Basic Research and Clinical Practice
  • Series Abbreviated Title Oxidative Stress
  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2014
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-1-4939-0678-9
  • Softcover ISBN 978-1-4939-4467-5
  • eBook ISBN 978-1-4939-0679-6
  • Series ISSN 2197-7224
  • Series E-ISSN 2197-7232
  • Edition Number 1
  • Number of Pages XII, 494
  • Number of Illustrations 62 b/w illustrations, 53 illustrations in colour
  • Topics Oxidative Stress
    Cell Biology
  • Buy this book on publisher's site