Tumor-Induced Immune Suppression

Mechanisms and Therapeutic Reversal

  • Dmitry I. Gabrilovich
  • Arthur Andrew Hurwitz

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Mary Jo Turk
    Pages 1-36
  3. Chrystal M. Paulos, Michelle H. Nelson, Xue-Zhong Yu
    Pages 37-75
  4. Mario P. Colombo, Paola Pittoni
    Pages 77-98
  5. Michael R. Shurin, Anton A. Keskinov, Gurkamal S. Chatta
    Pages 151-184
  6. Suzanne Ostrand-Rosenberg
    Pages 185-212
  7. Greg T. Motz, George Coukos
    Pages 213-238
  8. Kaori Sakuishi, Ana C. Anderson
    Pages 239-261
  9. Aimin Jiang, Katherine E. Stagliano, Steven M. Cuss, Ashley Triplett, Chunmei Fu, Arthur A. Hurwitz
    Pages 263-293
  10. Thomas Condamine, Indu R. Ramachandran, Dmitry I. Gabrilovich
    Pages 295-310
  11. George C. Prendergast, Courtney Smith, Sunil Thomas, Laura Mandik-Nayak, Lisa Laury-Kleintop, Richard Metz et al.
    Pages 311-346
  12. David M. Woods, Andressa Laino, Alejandro Villagra, Eduardo M. Sotomayor
    Pages 411-433
  13. Back Matter
    Pages 463-464

About this book

Introduction

Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer  and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs.

The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy  to provide breakthroughs in cancer treatment.  It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance,  but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune  suppression to make any progress in the field and this monograph provides these important insights.

Keywords

immune suppression mechanisms therapeutic reversal tumor

Editors and affiliations

  • Dmitry I. Gabrilovich
    • 1
  • Arthur Andrew Hurwitz
    • 2
  1. 1.Translational Tumor ImmunologyThe Wistar InstitutePhiladelphiaUSA
  2. 2.N PotomacUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4899-8056-4
  • Copyright Information Springer Science+Business Media, LLC 2014
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4899-8055-7
  • Online ISBN 978-1-4899-8056-4
  • About this book