Aspergillus and Aspergillosis

  • Hugo Vanden Bossche
  • Donald W. R. Mackenzie
  • Geert Cauwenbergh

Table of contents

  1. Front Matter
    Pages i-x
  2. Keynote Lecture

    1. Donald W. R. Mackenzie
      Pages 1-8
  3. Description — Epidemiology — Ecology — Diagnosis

    1. Front Matter
      Pages 9-9
    2. H. P. R. Seeliger, K. Tintelnot
      Pages 23-34
    3. Nicole Nolard, Monique Detandt, Hugues Beguin
      Pages 35-41
    4. Veronica M. Hearn
      Pages 43-71
  4. Immunology — Pathology — Host Defence

    1. Front Matter
      Pages 73-73
    2. Sotiros D. Chaparas, Sang Jae Kim
      Pages 75-85
    3. W. J. Stevens
      Pages 87-95
    4. Armand De Coster, Paul Dierckx, André Grivegnée
      Pages 107-114
    5. H. Takahashi, K. Chikakane, S. Hanawa, M. Okuda, M. Hatano, K. Kikuchi et al.
      Pages 121-128
    6. Eric D. Spitzer, George S. Kobayashi
      Pages 129-132
  5. Biochemistry — Mechanisms Of Action — Morphology

    1. Front Matter
      Pages 133-133
    2. Michael A. Gealt, Brian E. Shapiro, Theresa A. Lindley, Joseph L. Evans
      Pages 135-145
    3. David Kerridge
      Pages 147-160
    4. G. Medoff
      Pages 161-164
    5. Hugo Vanden Bossche, Patrick Marichal, Hugo Geerts, Paul A. J. Janssen
      Pages 171-197
    6. M. Borgers, M.-A. Van de Ven, J. Van Cutsem
      Pages 199-211
  6. Treatment of Aspergillosis and Aspergilloma

    1. Front Matter
      Pages 213-213
    2. John R. Graybill
      Pages 229-242
    3. Bertrand Dupont, Edouard Drouhet
      Pages 243-251
    4. A. Restrepo, M. I. Múnera, I. D. Arteaga, I. Gómez, A. M. Tabares, M. M. Patiño et al.
      Pages 253-265
    5. Philip A. Thomas, J. Rajasekaran
      Pages 267-279
  7. Prophylaxis

    1. Front Matter
      Pages 281-281
    2. H. P. R. Seeliger
      Pages 299-301
  8. Back Matter
    Pages 303-322

About this book


Species of aspergilli are common in man's environment and are responsible for a wide spectrum of human and animal disease, ranging in animals from mycotic abortion to aflatoxicosis and in humans from localized colonization of the ear or skin to life-threatening systemic infection of neutropenic patients. In recent times, invasive aspergillosis has become increasingly important as a cause of morbidity and death, initially in patients receiving immunosuppression prior to organ transplantation, and latterly in haematologic patients rendered neutropenic by underlying disease or chemotherapy. In some centres, the condition has been recorded in more than 40% of patients dying with acute leukaemia. Laboratory diagnostic procedures are not always helpful and the diagnosis depends largely on clinical parameters. The clinician is faced with yet another problem, that of management. At present, antifungal therapy of invasive aspergillosis can be largely ineffectual, and the mortality rate remains unacceptably high. Since Aspergillus fumigatus was first described almost 125 years ago, several other pathogenic species have been recognized. The marked biosynthetic abilities and varied mechanisms of gene recombination of aspergilli have long commanded attention in food technology and genetics. Their equally varied abilities to cause disease have attracted the interest of toxicologists, allergists and physicians concerned with infectious diseases.


animals environment food gene genes genetics immunosuppression infection infectious disease

Editors and affiliations

  • Hugo Vanden Bossche
    • 1
  • Donald W. R. Mackenzie
    • 2
  • Geert Cauwenbergh
    • 1
  1. 1.Janssen Research FoundationBeerseBelgium
  2. 2.Mycological Reference LaboratoryLondonUK

Bibliographic information