Antidepressants for Elderly People

  • Karabi¬†Ghose

Table of contents

  1. Front Matter
    Pages i-x
  2. The Nature and Presentation of Depression

    1. Front Matter
      Pages 1-1
    2. Vimal K. Sharma, John R. M. Copeland
      Pages 3-11
    3. Anthony J. Bayer, M. S. John Pathy
      Pages 13-25
  3. Lithium Salts

    1. Front Matter
      Pages 65-65
    2. John H. Lazarus
      Pages 67-83
    3. Karabi Ghose
      Pages 85-102
    4. Karabi Ghose, Alec Coppen
      Pages 103-114
  4. Tricyclic and Related Antidepressants

    1. Front Matter
      Pages 115-115
    2. Peter Crome, Sheila Dawling
      Pages 117-136
    3. Malcolm Peet
      Pages 137-162
    4. Jila Dana-Haeri, Steven J. Warrington
      Pages 163-179
  5. Monoamine Oxidase Inhibitor Antidepressants

    1. Front Matter
      Pages 199-199
    2. Diana Cody, Cosmo Hallstrom
      Pages 201-216
  6. General Management

    1. Front Matter
      Pages 217-217
    2. Hilary Standish-Barry
      Pages 219-233
    3. I. C. A. Moyes
      Pages 269-277
    4. Klaus P. Ebmeier, George W. Ashcroft
      Pages 279-290
  7. Back Matter
    Pages 291-302

About this book


Depression is one of the commonest problems in old age. Yet until recently, old people were systematically exduded from participating in drug trials and similar investigations. As a result, knowledge regarding incidence, natural history and management of depression in the elderly are somewhat limited. It is now well-established that old people are sensitive to most psychotropic drugs and they tend to suffer from adverse effects and side effects of antidepressant drugs more frequently than any other age group. These are considered to be due to age-related physiological changes. In addition, because of the frequent association with multiple pathology, the elderly are likely to receive polypharmacy which further complicates the management of antidepressant drug therapy. The aim of this book is to provide a comprehensive guidance on the drug therapy of depression for the dinicians involved in the health care of the elderly. In the first section, epidemiology, presentations and assessment of depression in old age and neuroendocrine abnormalities observed in patients with depression are briefly discussed. However, it mainly deals with the problems of antidepressant drug therapy, such as which antidepressant to prescribe, how to monitor efficacy and side effects, what is the adequate dose, how long to treat a single episode of depression and who requires long term medication. Information regarding pharmacology, side effects, adverse effects, drug interaction and pharmacokinetics of most currently available drugs are provided. Special emphasis has been given on continuation therapy and the choice of an antidepressant drug and their long term safety.


depression drug kinetics pharmacokinetics pharmacology pharmacy

Editors and affiliations

  • Karabi¬†Ghose
    • 1
  1. 1.University of Wales College of MedicineUK

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 1989
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-412-32460-4
  • Online ISBN 978-1-4899-3436-9
  • Buy this book on publisher's site