Central D1 Dopamine Receptors

  • Menek Goldstein
  • Kjell Fuxe
  • Irving Tabachnick

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 235)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Charles C. Ouimet, Hugh C. Hemmings Jr., Paul Greengard
    Pages 1-17
  3. John W. Kebabian
    Pages 19-31
  4. Susan E. Senogles, Nourdine Amlaiky, Joel G. Berger, Marc G. Caron
    Pages 33-41
  5. Menek Goldstein, Jow Y. Lew, Emanuel Meller
    Pages 43-53
  6. K. Fuxe, L. F. Agnati, A. Cintra, K. Andersson, P. Eneroth, A. Härfstrand et al.
    Pages 83-119
  7. Emanuel Meller, Menek Goldstein, Arnold J. Friedhoff, Jack W. Schweitzer
    Pages 121-136
  8. Allen Barnett, Louis C. Iorio, Robert McQuade, Richard E. Chipkin
    Pages 137-144
  9. Judith R. Walters, Joanne H. Carlson, Barton G. Weick, Debra A. Bergstrom
    Pages 145-158
  10. H. Rosengarten, J. W. Schweitzer, M. Egawa, A. J. Friedhoff
    Pages 159-167
  11. Ennio Ongini
    Pages 169-178
  12. Back Matter
    Pages 179-183

About this book

Introduction

The development of a selective D1 dopamine (DA) receptor antagonist SCH 23390 stimulated a number of studies on the functions mediated by central DA receptor subtypes. It was generally assumed that the central D1 DA receptor isa molecular entity whose function awaits further discovery. The papers presented in this volume clearly show that this is no longer the case and that D1 DA receptors have many behavioral fuctions which might be altered in pathological states. A number of papers have recognized the interdependence of the regulatory functions of the D1 DA receptors with D2 and other receptor proteins, and vice versa. The biochemical, pharmacological and morphological characterization of the D1 and D2 DA receptor binding proteins, as well as of DARPP-32, illustrates the complex interactions between various macromolecules. Procedures described for the purification of the D1 and D2 DA receptor subtypes are fundamental for future studies on the mechanisms involved in the coupling of the receptor proteins with signal transducing systems. Several studies in this volume show that D1 DA receptors have behavioral functions and that they are often similar to the responses mediated by D2 DA receptors, but in some instances reflect divergent neuronal activity of both systems. The knowledge of the physiology and biochemistry of the central DA receptor subtypes could lead to the development of a new generation of drugs which ameliorate some mental and neurological dysfunctions without producing severe undesirable side effects.

Keywords

biochemistry interaction interdependence media physiology proteins regulation

Editors and affiliations

  • Menek Goldstein
    • 1
  • Kjell Fuxe
    • 2
  • Irving Tabachnick
    • 3
  1. 1.New York University Medical CenterNew YorkUSA
  2. 2.Karolinska InstituteStockholmSweden
  3. 3.Schering CorporationBloomfieldUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4899-2723-1
  • Copyright Information Springer-Verlag US 1988
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4899-2725-5
  • Online ISBN 978-1-4899-2723-1
  • Series Print ISSN 0065-2598
  • About this book