Purine and Pyrimidine Metabolism in Man VII

Part A: Chemotherapy, ATP Depletion, and Gout

  • R. Angus Harkness
  • Gertrude B. Elion
  • Nepomuk Zöllner

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 309A)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Chemotherapy

    1. Historical Development

      1. George H. Hitchings
        Pages 1-6
    2. Cancer and AIDS Treatment

      1. Stephen J. Clarke, Ann L. Jackman, Kenneth R. Harrap
        Pages 7-13
      2. Carlos J. Carrera, Lawrence D. Piro, Alan Saven, Ernest Beutler, Chihiro Terai, Dennis A. Carson
        Pages 15-18
      3. Ann L. Jackman, Duncan I. Jodrell, William Gibson, Trevor C. Stephens
        Pages 19-23
      4. R. C. Trueworthy, R. A. DeAbreu, L. H. J. Lambooy, J. P. M. Bökkerink, E. H. Stet
        Pages 25-28
      5. Kenneth L. Powell, Dorothy J. Purifoy
        Pages 33-40
    3. Development and Effects of New Analogues

      1. Richard B. Gilbertsen, Mi K. Dong, David J. Wilburn, Lynn M. Kossarek, Jagadish C. Sircar, Catherine R. Kostlan et al.
        Pages 41-44
      2. Larry L. Bondoc Jr., Brian L. Robbins, Gurpreet S. Ahluwalia, Hiroaki Mitsuya, David G. Johns, Arnold Fridland
        Pages 49-53
      3. D. A. Bullough, C. Zhang, K. M. Mullane
        Pages 55-55
      4. Veronique W. T. Ruiz van Haperen, Gijsbert Veerman, Paul Noordhuis, Jan B. Vermorken, Godefridus J. Peters
        Pages 57-60
    4. Analogue Effects and Metabolism

      1. Pedro R. Chocair, John A. Duley, H. Anne Simmonds, J. Stewart Cameron
        Pages 61-64
      2. K. Ganeshaguru, W. C. P. de Mel, G. Sissolak, D. Catovsky, C. E. Dearden, A. B. Mehta et al.
        Pages 65-68
      3. John Galivan, Myung Rhee, David G. Priest, Marlene Bunni, James H. Freisheim, John M. Whiteley
        Pages 75-78
      4. Hiroshi Tsutani, Daizaburo Kagawa, Michihiko Uchida, Teruo Yoshimura, Tsuneo Tanaka, Takanori Ueda et al.
        Pages 79-82
      5. E. H. Stet, R. A. De Abreu, Y. P. G. Janssen, J. P. M. Bökkerink, J. M. F. Trijbels
        Pages 83-86
      6. Ronney A. De Abreu, Frank van Strien, Lambert H. J. Lambooy, J. P. M. Bökkerink
        Pages 87-91
      7. A. Lucano, C. Crifò, C. Salerno
        Pages 93-96
      8. Clasina L. Van der Wilt, Andreas Marinelli, Jacqueline Cloos, Kees Smid, Herbert M. Pinedo, Godefridus J. Peters
        Pages 105-108
    5. Metabolic Studies in Cancer Cells

      1. Tilman Grune, Werner Siems, Rolf Uhlig, Peter Langen, Gerhard Gerber
        Pages 109-112
      2. A. André van den Berg, Henk van Lenthe, Dirk de Korte, Dirk Roos, Albert H. van Gennip
        Pages 117-120
      3. Antonella Tabucchi, Filippo Carlucci, Roberto Pagani, Franca Ciccomascolo, Lucia Lopalco, Antonio Siccardi
        Pages 121-124
    6. Pyrimidine Analogues

      1. Varsha Gandhi, Peng Huang, Yi-Zheng Xu, Volker Heinemann, William Plunkett
        Pages 125-130
      2. Godefridus J. Peters, Cees J. van Groeningen, Clasina L. van der Wilt, Kees Smid, Sybren Meijer, Herbert M. Pinedo
        Pages 131-134
    7. Hypouricaemic Compounds

      1. Seiji Sato, Kunihiko Tatsumi, Takeshi Nishino
        Pages 135-138
      2. Irmingard Kamilli, Ursula Gresser, Christof Schaefer, Nepomuk Zöllner
        Pages 143-145
      3. Ursula Gresser, Helmut Empl, Irmingard Kamilli, Nepomuk Zöllner
        Pages 147-150
      4. Yuji Moriwaki, Tetsuya Yamamoto, Sumio Takahashi, Michio Suda, Oluyemi E. Agbedana, Toshikazu Hada et al.
        Pages 151-155
    8. Parasitic Diseases

    9. Enzyme Replacement

  3. Gout and Uric Acid

    1. Dominique Werner, Barbara Guisan, Françoise Roch-Ramel
      Pages 177-180
    2. B. T. Emmerson, S. L. Nagel, J. O’Connor, D. L. Duffy, N. G. Martin
      Pages 181-183
    3. J. Stewart Cameron, Fernando Moro, H. Anne Simmonds
      Pages 185-189
    4. Mary B. McBride, Venkat Raman, Chisholm S. Ogg, Cyril Chantler, J. S. Cameron, John A. Duley et al.
      Pages 191-194
    5. Juan G. Puig, Ma. E. Miranda Carús, Felícitas A. Mateos, Ma. Luz Picazo, M. López Jiménez, J. Ortíz Vázquez
      Pages 195-198
    6. Fernando Moro, H. Anne Simmonds, J. Stewart Cameron, Chisholm S. Ogg, Gwyn D. Williams, Mary B. McBride et al.
      Pages 199-202
    7. G. Nuki, M. L. Watson, B. C. Williams, H. A. Simmonds, R. C. Wallace
      Pages 203-208
    8. Ma. Eugenia Miranda, Juan G. Puig, Felícitas A. Mateos, Teresa H. Ramos, Elisa Herrero, Antonio González et al.
      Pages 209-212
    9. Takamichi Nishimura, Ikuo Mineo, Takao Shimizu, Masanori Kawachi, Akira Ono, Hiromu Nakajima et al.
      Pages 213-216
    10. Sumio Takahashi, Tetsuya Yamamoto, Yuji Moriwaki, Michio Suda, Oluyemi E. Agbedana, Toshikazu Hada et al.
      Pages 217-221

About this book


These two volumes record the scientific and clinical work presented at the VIIth International and 3rd European joint symposium on purine and pyrimidine metabolism in man held at the Bournemouth International Conference Centre, Bournemouth, UK, from 30th June to 5th July 1991. The series of international meetings at three yearly intervals have previously been held initially in 1973 in Israel, then Austria, Spain, the Netherlands, USA and Japan. The European society for the Study of Purine and Pyrimidine Metabolism in Man (ESSPPM) which has its own executive and some finance first met in Switzerland in 1987, then in Germany in 1989. The steady evolution of the science in this series of meetings is intellectually satisfying; the subsequent clinical progress is emotionally and economically reassuring. As befits the position of purines and pyrimidines at the centre of biochemistry, there has been steady scientific development into molecular genetics and now onto developmental controls and biochemical pharmacology. The complexities of the immune system are being unravelled but an understanding of the human brain largely eludes us. Laboratory based scientists now predominate over those who work as clinical specialists in vii rheumatology, immunology, oncology and paediatrics. However, there continue to be major clinical objectives since large sections are concerned with major causes of death like ATP depletion, cancer and now AIDS; the laboratory work is providing clinical solutions.


ATP Coenzym Colon DNA Lipid Nucleotide Purine Pyrimidine enzymes metabolism

Editors and affiliations

  • R. Angus Harkness
    • 1
  • Gertrude B. Elion
    • 2
  • Nepomuk Zöllner
    • 3
  1. 1.Institute of Child HealthLondonUK
  2. 2.Burroughs Wellcome Co.Research Triangle ParkUSA
  3. 3.Universität MünchenMünchenGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1991
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4899-2640-1
  • Online ISBN 978-1-4899-2638-8
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site