Protein Pharmacokinetics and Metabolism

  • Bobbe L. Ferraiolo
  • Marjorie A. Mohler
  • Carol A. Gloff

Part of the Pharmaceutical Biotechnology book series (PBIO, volume 1)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Bobbe L. Ferraiolo, Marjorie A. Mohler
    Pages 1-33
  3. Marjorie A. Mohler, Jennifer E. Cook, Gerhard Baumann
    Pages 35-71
  4. Jerome A. Moore, Victor J. Wroblewski
    Pages 93-126
  5. Carol A. Gloff, Robert J. Wills
    Pages 127-150
  6. Paul A. Cossum, Robert A. Baughman Jr.
    Pages 151-187
  7. Back Matter
    Pages 271-275

About this book


Investigation of the pharmacokinetics and metabolism of human proteins has escalated over the last two decades because of the use of recombinant human proteins as therapeutic agents. In addition, the development and improvement of analytical techniques enabling the detection of minute quantities of proteins in biological matrices have aided this process. In assembling this volume, we sought to provide a state-of-the-art as­ sessment of the pharmacokinetics and metabolism of protein therapeutics through complete reviews of selected examples. A comprehensive review of all protein therapeutics was not attempted; the majority -of the therapeutic protein classes and crucial scientific issues have been addressed, however. Therefore, we are confident that this volume will provide a useful reference for scientists in this field. The volume has been divided into two general parts. The first part (Chapters 1-3) is composed of general reviews of topics of importance in pharmacokinetic/metabolism studies of proteins: goals and analytical meth­ odologies, effects of binding proteins, and effects of antibody induction, respectively. The second part (Chapters 4-8) consists of specific, detailed reviews by therapeutic protein class: growth factors and hormones, cyto­ kines, cardiovascular proteins, hematopoietic proteins, and antibodies, respectively. The editors are grateful to the contributors for the patience, personal sacrifice and perseverance required to complete this volume. BoDDE L. FERRAIOLO MARJORIE A. MOHLER CAROL A. GLOFF ix Contents Chapter 1 Goals and Analytical Methodologies for Protein Disposition Studies Bobbe L. Ferraiolo and Marjorie A. Mohler 1. Introduction ................................................. .


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Editors and affiliations

  • Bobbe L. Ferraiolo
    • 1
  • Marjorie A. Mohler
    • 2
  • Carol A. Gloff
    • 3
  1. 1.R. W. Johnson Pharmaceutical Research InstituteSpring HouseUSA
  2. 2.Genentech, Inc.South San FranciscoUSA
  3. 3.Alkermes, Inc.CambridgeUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1992
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4899-2331-8
  • Online ISBN 978-1-4899-2329-5
  • Series Print ISSN 1078-0467
  • Buy this book on publisher's site