Modern Vaccinology

  • Edouard Kurstak

Table of contents

  1. Front Matter
    Pages i-ix
  2. Editor’s Introduction

  3. New Concepts in Vaccines Development and Immune Response

    1. Front Matter
      Pages 11-11
    2. Jeffrey B. Ulmer, John J. Donnelly, Margaret A. Liu
      Pages 13-23
    3. Francis E. André, William J. Stanbury, Dirk E. Teuwen
      Pages 41-54
    4. Steven N. Chatfield, Gordon Dougan, Mark Roberts
      Pages 55-86
  4. Recombinant Vaccines and Multivalent Immunogens

    1. Front Matter
      Pages 119-119
    2. John A. Tine, Jill Taylor, Enzo Paoletti
      Pages 121-151
    3. Timo Vesikari, Albert Z. Kapikian
      Pages 213-229
    4. Connie S. Schmaljohn, Joel M. Dalrymple, David McClain
      Pages 253-263
    5. Jill Taylor, Enzo Paoletti
      Pages 265-281
    6. M. Ewasyshyn, Michel Klein
      Pages 283-301
    7. P.-P. Pastoret, B. Brochier, D. Boulanger, G. Chappuis, M. P. Kieny
      Pages 303-318
    8. Sheena Loosmore, Gavin Zealey, Michel Klein
      Pages 319-340
    9. Raymond J. Pierce, André R. Capron
      Pages 357-380
  5. Back Matter
    Pages 381-397

About this book


The recent developments in modern vaccinology are mainly based on: (i) cloning of microbial genes into recombinant vectors containing genetic information for expression of desired neutralizing immunogens; (ii) alternatives of attenuated vectors with deleted genes permitting the insertion of several foreign genes expressing antigens exposed to the host immune system during the abortive replication of such vectors; (iii) combined vaccines with the aim to protect against many diseases with a limited number of administrations; (iv) evidence demonstrating the ability of animals to respond serologically to DNA injections considered as a potential method of vaccination; (v) the possibility to manipulate the immune system with new and improved immunomodulators enhancing the immune response; and (vi) new microcarrier systems for particular immunogens or immunomodulators delivery, either in a single dose or sustained release, and presentation to the immune system for a relevant response. New vaccines being developed are mainly based on viral, bacterial or other vectors modified with genetic engineering technology, to possess and express desired antigens for vaccination against single or multiple infections. Existing combined vaccines like diphtheria, tetanus, pertussis (DTP) are also experimented with new additional components like recombinant hepatitis B virus surface antigen, inactivated poliovirus, and Haemophilus inJluenzae type b immunogens, in order to produce multivalent vaccines. Such types of vaccines permitting the reduction of multiple medical visits is of particular interest to pediatric immuni­ zation programs, and would benefit especially the developing countries assuring better vaccine compliance with immunization schedules.


AIDS Antigen Hepatitis Virus infectious infectious disease infectious diseases

Editors and affiliations

  • Edouard Kurstak
    • 1
    • 2
  1. 1.University of MontrealMontrealCanada
  2. 2.World Health OrganizationGenevaSwitzerland

Bibliographic information