Toxin-Induced Models of Neurological Disorders

  • Michael L. Woodruff
  • Arthur J. Nonneman

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Arthur J. Nonneman, Michael L. Woodruff
    Pages 1-15
  3. Paul R. Solomon, Maryellen Groccia-Ellison, Mark E. Stanton, William W. Pendlebury
    Pages 17-38
  4. Michael J. Strong, Ralph M. Garruto
    Pages 39-88
  5. Erik Sundström, Bengt G. Henriksson, Abdul H. Mohammed, Frédéric Souverbie
    Pages 121-137
  6. J. R. Taylor, J. D. Elsworth, R. H. Roth, J. R. Sladek Jr., D. E. Redmond Jr.
    Pages 139-174
  7. G. W. Arendash, G. J. Sengstock, C. W. Olanow, S. Barone Jr., A. J. Dunn
    Pages 175-212
  8. Dwaine F. Emerich, David W. Cahill, Paul R. Sanberg
    Pages 213-257
  9. Laura M. Juárez De Ku, Lee A. Meserve
    Pages 281-299
  10. Back Matter
    Pages 337-344

About this book


Tbis volume discusses and evaluates the use of neurotoxins to produce animal models of human neurodegenerative diseases. Tbe models presented use neuro­ toxins to induce some or most of the pathophysiological changes (including behavioral) that characterize the most studied motor neuron disorders and cogni­ tive disorders (dementia) in humans. Within the biomedical research community, there is little doubt about the utility of such models. But with increasing frequen­ cy, individuals concemed with animal rights question the validity of such models and argue that they actually produce no useful information for understanding or developing treatments for human disorders. Each of the chapters will address this issue, considering the utility, validity, generalizability, and limitations of the models presented. Chapter 1 begins with a brief review of the ethics of animal use in neuro­ biological research, inc1uding a discussion of the criteria that may be used to evaluate animal models of human disease and extrapolate from the model to appropriate questions regarding humans. The limitations of such extrapolation are also discussed, with special consideration of issues specific to the use of neurotoxins. Chapter 2 extends this theme with further consideration of issues and strategies involved in developing neurotoxin-induced models of neuro­ degenerative disorders and assessing risk factors associated with neurotoxin ex­ posure. It then narrows to evaluate the use of a model systems approach to explore neurotoxin-induced leaming and memory deficits in animals as related to humans with dementia.


Alzheimer Parkinson dopamine neurons neuroscience neurotoxicity

Editors and affiliations

  • Michael L. Woodruff
    • 1
  • Arthur J. Nonneman
    • 2
  1. 1.East Tennesee State UniversityJohnson CityUSA
  2. 2.Asbury CollegeWilmoreUSA

Bibliographic information