Neural and Muscular Mechanisms

  • Simon C. Gandevia
  • Roger M. Enoka
  • Alan J. McComas
  • Douglas G. Stuart
  • Christine K. Thomas
  • Patricia A. Pierce

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 384)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Looking Back

    1. Brenda R. Bigland-Ritchie
      Pages 1-9
  3. The Scientific Contributions of Brenda Bigland-Ritchie

    1. C. K. Thomas, R. M. Enoka, S. C. Gandevia, A. J. McComas, D. G. Stuart
      Pages 11-25
  4. Fatigue of Single Muscle Fibers

    1. Front Matter
      Pages 27-28
    2. D. G. Stephenson, G. D. Lamb, G. M. M. Stephenson, M. W. Fryer
      Pages 45-56
    3. D. G. Allen, H. Westerblad, J. Lännergren
      Pages 57-68
    4. G. Sjøgaard, A. J. McComas
      Pages 69-80
  5. Fatigue at the Neuromuscular Junction

    1. Front Matter
      Pages 81-82
    2. G. C. Sieck, Y. S. Prakash
      Pages 83-100
    3. J. V. Trontelj, E. Stålberg
      Pages 109-119
  6. Fatigue of Single Motor Units

    1. Front Matter
      Pages 121-122
    2. A. Sawczuk, R. K. Powers, M. D. Binder
      Pages 123-134
  7. Fatigue Studied with NMR Techniques

    1. Front Matter
      Pages 173-174
    2. M. J. Kushmerick
      Pages 175-184
    3. R. G. Miller, J. A. Kent-Braun, K. R. Sharma, M. W. Weiner
      Pages 195-210
    4. L. A. Bertocci
      Pages 211-223
  8. The Case for Segmental Motor Mechanisms

    1. Front Matter
      Pages 225-226
    2. K-E. Hagbarth, V. G. Macefield
      Pages 259-270
  9. The Case for Central Fatigue

    1. Front Matter
      Pages 279-280
    2. S. C. Gandevia, G. M. Allen, D. K. McKenzie
      Pages 281-294
    3. D. Popivanov, A. Mineva, J. Dushanova
      Pages 295-304
  10. Task Dependency of Fatigue Mechanisms

    1. Front Matter
      Pages 321-322
    2. B. Bigland-Ritchie, C. L. Rice, S. J. Garland, M. L. Walsh
      Pages 361-380
  11. Integrative Systems Issues

    1. Front Matter
      Pages 381-382
    2. S. L. Lindstedt, H. Hoppeler
      Pages 383-391
    3. J. A. Dempsey, M. A. Babcock
      Pages 393-399
    4. D. K. McKenzie, F. Bellemare
      Pages 401-414
    5. T. S. Miles, M. A. Nordstrom
      Pages 415-426
  12. Fatigue of Adapted Systems: Overuse, Underuse and Pathophysiology

    1. Front Matter
      Pages 427-428
    2. T. Gordon
      Pages 429-456
    3. P. M. Clarkson, D. J. Newham
      Pages 457-469
    4. J. A. Faulkner, S. V. Brooks
      Pages 471-480
    5. A. J. McComas, R. G. Miller, S. C. Gandevia
      Pages 495-512
  13. Epilogue

    1. Front Matter
      Pages 513-513
    2. S. C. Gandevia, R. M. Enoka, A. J. McComas, D. G. Stuart, C. K. Thomas
      Pages 515-525

About this book


This volume describes the current state of our knowledge on the neurobiology of muscle fatigue, with consideration also given to selected integrative cardiorespiratory mechanisms. Our charge to the authors of the various chapters was twofold: to provide a systematic review of the topic that could serve as a balanced reference text for practicing health-care professionals, teaching faculty, and pre-and postdoctoral trainees in the biomedi­ cal sciences; and to stimulate further experimental and theoretical work on neurobiology. Key issues are addressed in nine interrelated areas: fatigue of single muscle fibers, fatigue at the neuromuscular junction, fatigue of single motor units, metabolic fatigue studied with nuclear magnetic resonance, fatigue of the segmental motor system, fatigue involving suprasegmental mechanisms, the task dependency of fatigue mechanisms, integrative (largely cardiorespiratory) systems issues, and fatigue of adapted systems (due to aging, under-and overuse, and pathophysiology). The product is a volume that provides compre­ of processes that operate from the forebrain to the contractile proteins.


axon biology muscle nervous system neurobiology nuclear magnetic resonance (NMR) pathophysiology physiology skeletal muscle

Editors and affiliations

  • Simon C. Gandevia
    • 1
  • Roger M. Enoka
    • 2
  • Alan J. McComas
    • 3
  • Douglas G. Stuart
    • 4
  • Christine K. Thomas
    • 5
  • Patricia A. Pierce
    • 4
  1. 1.Prince of Wales Medical Research InstituteSydneyAustralia
  2. 2.The Cleveland Clinic FoundationClevelandUSA
  3. 3.McMaster UniversityHamiltonCanada
  4. 4.The University of ArizonaTucsonUSA
  5. 5.University of MiamiMiamiUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1995
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4899-1018-9
  • Online ISBN 978-1-4899-1016-5
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site