The Carbonic Anhydrases

Cellular Physiology and Molecular Genetics

  • Susanna J. Dodgson
  • Richard E. Tashian
  • Gerolf Gros
  • Nicholas D. Carter

Table of contents

  1. Front Matter
    Pages i-xviii
  2. The Carbonic Anhydrase Isozymes

    1. Front Matter
      Pages 1-1
    2. Susanna J. Dodgson
      Pages 3-14
    3. David Hewett-Emmett, Richard E. Tashian
      Pages 15-32
    4. A. Elisabeth Eriksson, Anders Liljas
      Pages 33-48
    5. Raja G. Khalifah, David N. Silverman
      Pages 49-70
  3. Carbonic Anhydrase Analysis

  4. Carbonic Anhydrases in Clinical Medicine

    1. Front Matter
      Pages 161-161
    2. Marianne E. Feitl, Theodore Krupin
      Pages 163-170
    3. Erik A. Lippa
      Pages 171-181
    4. William S. Sly
      Pages 183-193
  5. Genetic Regulation of the Carbonic Anhydrase Isozymes

    1. Front Matter
      Pages 195-195
    2. Peter H. W. Butterworth, Jonathan H. Barlow, Hugh J. M. Brady, Mina Edwards, Nicholas Lowe, Jane C. Sowden
      Pages 197-207
    3. William Thierfelder, Patrick Cummings, Peter Fraser, Peter J. Curtis
      Pages 209-214
  6. Muscle Carbonic Anhydrases

    1. Front Matter
      Pages 225-225
    2. Cornelia Geers, Gerolf Gros
      Pages 227-240
    3. Pierre Frémont, Pierre M. Charest, Claude Côté, Peter A. Rogers
      Pages 241-246
    4. Bayard T. Storey
      Pages 257-262
  7. Carbonic Anhydrases of the Gastrointestinal Tract

  8. The Carbonic Anhydrases of Other Organs

    1. Front Matter
      Pages 307-307
    2. Shoko Nioka, Robert E. Forster II
      Pages 333-340
    3. Susanna J. Dodgson
      Pages 345-350
    4. H. Kalervo Väänänen, Eeva-Kaisa Parvinen
      Pages 351-355
    5. Susan F. Silverton
      Pages 357-363
    6. Ross T. Fernley
      Pages 365-373
  9. Back Matter
    Pages 375-379

About this book


As we approach the twenty-first century the problems of industrialization are evident: we find there is a greenhouse effect, the ozone layer is being depleted, the rain is acidified, and there is a terrible problem of increasing C0 concentrations in the atmo­ 2 sphere. The carbonic anhydrases are a unique family of enzymes that solve these problems in the human body: they are responsible for converting C0 (a gas) to 2 HC0-, which is the biggest intracellular buffer, with a concomitant decrease in a 3 hydroxyl ion. Globally, the functions of the carbonic anhydrases in photosynthesis in rain forests and in the algae and plankton that cover our oceans indicate that they are also of utmost importance in the maintenance of the acid-base balance on our planet. Although the whole field of C0 metabolism is enormous and still rapidly 2 expanding, because of the research interests of the editors this book is mainly concerned with mammalian carbonic anhydrases. However, if the interested reader intends to purify carbonic anhydrases from nonmammalian sources, Dr. Cheg­ widden has provided the necessary information in Chapter 7. The carbonic anhydrases were first discovered in 1933; until1976 there were thought to be only two isozymes. Since then CA ill, IY, V, VI, and Vll have been discovered and well characterized. There is, of course, no reason to believe that we have found them all.


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Editors and affiliations

  • Susanna J. Dodgson
    • 1
  • Richard E. Tashian
    • 2
  • Gerolf Gros
    • 3
  • Nicholas D. Carter
    • 4
  1. 1.Department of Physiology, School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of Human GeneticsUniversity of Michigan Medical SchoolAnn ArborUSA
  3. 3.Zentrum PhysiologieMedizinische Hochschule HannoverHannover 61Federal Republic of Germany
  4. 4.Department of Child Health, St. George’s Hospital Medical SchoolUniversity of LondonLondonUK

Bibliographic information