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Reproductive Toxicology

In Vitro Germ Cell Developmental Toxicology, from Science to Social and Industrial Demand

  • Jesús del Mazo
Book

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 444)

Table of contents

  1. Front Matter
    Pages i-xi
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  2. Advances in Improving Human Risk Estimation

    1. Trends in Male Reproductive Health. Environmental Aspects
      Niels E. Skakkebaek
      Pages 1-4
    2. Organochlorine Compounds and Xenoestrogens in Human Endometrium
      Wolfgang R. Schäfer, Hans Peter Zahradnik
      Pages 5-8
    3. Assays to Measure Estrogen and Androgen Agonists and Antagonists
      Ana M. Soto, Cheryl L. Michaelson, Nancy V. Prechtl, Beau C. Weill, Carlos Sonnenschein, Fatima Olea-Serrano et al.
      Pages 9-28
    4. Development of a Marker of Estrogenic Exposure in Breast Cancer Patients
      Patricia Pazos, Pilar Pérez, Ana Rivas, Rafael Nieto, Begoña Botella, Jorge Crespo et al.
      Pages 29-40

  3. New Approaches for In Vitro Analysis of Germ Cells Exposure to Toxicological Agents

    1. In Vitro Culture Systems for Germ Cells from Mouse Embryo: Primordial Germ Cells and Oocytes
      Massimo De Felici
      Pages 41-49
    2. Cell Culture Systems for the Analysis of the Male Germinal Differentiation
      Minoo Rassoulzadegan, François Cuzin
      Pages 51-57
    3. In Vitro Survival of Human Neoplastic Germ Cells
      Ewa Rajpert-De Meyts, Heidrun Lauke, Niels E. Skakkebæk
      Pages 59-66
    4. Effects of Rapamycin and FK 506 on Rat Sertoli Cells In Vitro
      Nicole Clemann, Rudolf Bechter
      Pages 67-71
    5. Flow Cytometry as a Tool for the Evaluation of Testicular Toxicity
      Maria Bobadilla, Laura Suter, Rudolf Bechter
      Pages 73-78
    6. DNA Damage in Human and Mouse Spermatozoa after In Vitro-Irradiation Assessed by the Comet Assay
      Grant Haines, Brian Marples, Paul Daniel, Ian Morris
      Pages 79-93
    7. In Vitro Models for the Investigation of Reproductive Toxicology in the Testis
      Brian A. Cooke
      Pages 95-103
    8. Effect of Metal Compounds on Boar Sperm Motility In Vitro
      Mario Altamirano-Lozano, Elia Roldán, Edmundo Bonilla, Miguel Betancourt
      Pages 105-111
    9. In Vitro Analysis of Xenoestrogens by Enzyme Linked Receptor Assays (ELRA)
      Martin Seifert, Stefanie Haindl, Bertold Hock
      Pages 113-117

  4. Molecular and Developmental Approaches for Assessing Reproductive Toxicity:

    1. Current and Future Contributions of Transgenic Mice to the Analysis of Germline Toxicology
      A. Collick, Philippe Bois, Gemma Grant, Jerome Buard
      Pages 119-127
    2. Evaluation of the Placenta: Suggestions for a Greater Role in Developmental Toxicology
      F. Maranghi, C. Macrì, C. Ricciardi, A. V. Stazi, A. Mantovani
      Pages 129-136
    3. Protective Mechanisms in Germ Cells: Stress Proteins in Spermatogenesis
      David J. Dix, Robert L. Hong
      Pages 137-144
    4. Molecular Cloning and Developmental Pattern of Expression of MSJ-1, a New Male Germ Cell-Specific DnaJ Homologue
      Giovanna Berruti, Lucia Perego, Enzo Martegani
      Pages 145-151
    5. Analysis of Gene Regulation in Sertoli Cells by a Gene Trap Approach
      Luis A. López-Fernández, Pascal Lopez, Fréderique Vidal, Fariba Ranc, François Cuzin, Minoo Rassoulzadegan
      Pages 153-162
    6. Biochemical Characterization of Benomyl Inhibition on Endometrial Growth During Decidualization in Rats
      Fitzgerald Spencer, Limen Chi, Ming-Xia Zhu
      Pages 163-169

  5. Animal Risk Assessment. In Vivo / In Vitro Comparative Analysis

    1. An Overview of Current In Vivo Test Procedures to Reproductive Toxicology
      Alfredo Nunziata
      Pages 171-183
    2. A New Assay to Asses Aneuploidy in Human-Hamster Embryos
      Immaculada Ponsa, Laura Tusell, Ricard Álvarez, Anna Genescà, Rosa Miró, Josep Egozcue
      Pages 185-190
    3. Single Day Treatment — A Feasible Tool in Revealing Not Dependent on Maternal Toxicity Teratogenic Potential
      T. Vergieva
      Pages 191-199
    4. The Effect of Parathion on Mouse Testicular and Epididymal Development Cultured in Chicken Allantochorion
      Mariana Rojas, Eduardo Bustos-Obregón, Francisco Martínez-García, Héctor Contreras, Javier Regadera
      Pages 201-206
    5. Evaluation of Xenoestrogenic Effects in Fish on Different Organization Levels
      Betting Schrag, Uwe Ensenbach, José Maria Navas, Helmut Segner
      Pages 207-214
    6. Effects on Female Fertility and Germinal Cells in Prepubertal and Adult Rats (Rattus norvegicus) after X-Ray Irradiation
      Ivan Martínez-Flores, Josep Egozcue, Montserrat Garcia
      Pages 215-219
  6. Back Matter
    Pages 221-223
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About this book

Introduction

Numerous reports demonstrate that the reproductive system could be affected by multiple potential toxicological agents. The volume includes different aspects of the development of new approaches to in vitro testing using sperm cells and systems involved on reproduction in mammals. Comparative analysis of in vivo and in vitro methods has been included to take steps towards the further development of and applications of new systems for germline toxicology.

Keywords

Drogen Embryo assessment development production

Editors and affiliations

  • Jesús del Mazo
    • 1
  1. 1.Centro de Investigaciones Biológicas (CISC)MadridSpain

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4899-0089-0
  • Copyright Information Springer-Verlag US 1998
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4899-0091-3
  • Online ISBN 978-1-4899-0089-0
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site