Optical Imaging of Brain Function and Metabolism 2

Physiological Basis and Comparison to Other Functional Neuroimaging Methods

  • Arno Villringer
  • Ulrich Dirnagl

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 413)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Signal Sources in Functional Neuroimaging

    1. Arno Villringer
      Pages 1-18
    2. Robert Turner
      Pages 19-25
    3. Kenneth K. Kwong, David A. Chesler
      Pages 27-34
    4. K. Herholz
      Pages 43-51
  3. New Technical Developments in Near Infrared Spectroscopy of the Brain

    1. Gabriele Gratton, Monica Fabiani, Paul M. Corballis
      Pages 53-62
    2. C. E. Cooper, M. Cope, V. Quaresima, M. Ferrari, E. Nemoto, R. Springett et al.
      Pages 63-73
    3. Yukito Shinohara, Munetaka Haida, Nobuaki Shinohara, Fumio Kawaguchi, Yoshitoshi Itoh, Hideaki Koizumi
      Pages 85-89
  4. Applications of NIRS for the Functional Assessment of Brain and Comparison to other Functional Neuroimaging Methods

    1. Mamoru Tamura, Yoko Hoshi, Osamu Hazeki, Fumihiko Okada
      Pages 91-96
    2. C. Hock, K. Villringer, H. Heekeren, M. Hofmann, R. Wenzel, A. Villringer et al.
      Pages 105-112
    3. Hellmuth Obrig, Arno Villringer
      Pages 113-127
    4. Christina Hirth, Kersten Villringer, Andreas Thiel, Johannes Bernarding, Werner Mühlnickl, Hellmuth Obrig et al.
      Pages 139-147
    5. Kersten Villringer, Satoshi Minoshima, Christoph Hock, Hellmuth Obrig, Sibylle Ziegler, Ulrich Dirnagl et al.
      Pages 149-153
  5. Coupling of Brain Activity and Cerebral Blood Flow and Functional Neuroimaging Methods

    1. Ulrich Dirnagl
      Pages 155-159
    2. Pierre J. Magistretti, Luc Pellerin
      Pages 161-166
    3. Wolfgang Kuschinsky
      Pages 167-176
    4. J. Frahm, G. Krueger, K. D. Merboldt, A. Kleinschmidt
      Pages 195-203
    5. Iwao Kanno, Eku Shimosegawa, Hedeaki Fujita, Jun Hatazawa
      Pages 209-214
    6. Dov Malonek, Amiram Grinvald
      Pages 215-220
  6. Multimodal Imaging of the Human Brain

    1. A. Kleinschmidt, J. Frahm
      Pages 221-233
    2. Thomas A. Zeffiro, G. F. Eden, R. P. Woods, J. W. VanMeter
      Pages 235-240
  7. Back Matter
    Pages 245-249

About this book


This volume covers the latest developments in optical imaging of the brain which is becoming an increasingly important functional neuroimaging method. Optical intrinsic signals offer unrivaled temporal and spatial resolution of functional measurements of the exposed brain cortex in animals and humans. Near-infrared spectroscopy and imaging ap­ proaches permit the noninvasive functional assessment of the human brain at bedside. Main advantages of these optical techniques are the biochemical specificity of the meas­ urements and the potential of measuring correlates of intracellular and intravascular oxy­ genation simultaneously. Recent data indicate that one may also measure a more direct correlate of neuronal activity associated with changes in light scattering. In this volume, recent technical progress of the optical method is covered as well as the physiological basis of the measurements. In simultaneous studies, near-infrared spec­ troscopy measurements are directly compared to other functional methods, especially PET and fMRI and examples are given for new applications of the NIRS-method. Based on re­ sults obtained with optical methods and other functional techniques the latest in our under­ standing of the coupling of neuronal activity and cerebral blood flow response is reviewed. This is an important basis for a better understanding of all functional neuroi­ maging methods which rely on neurovascular coupling such as PET, SPET and fMRI. Fi­ nally the optical method is put into the perspective of presently available functional neuroimaging methods including fMRI, PET, MEG and EEG.


imaging infrared spectroscopy metabolism optical imaging spectroscopy

Editors and affiliations

  • Arno Villringer
    • 1
  • Ulrich Dirnagl
    • 1
  1. 1.Universitätsklinikum CharitéHumboldt Universität zu BerlinBerlinGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1997
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4899-0058-6
  • Online ISBN 978-1-4899-0056-2
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site