Control of Metabolic Processes

  • Athel Cornish-Bowden
  • María Luz Cárdenas

Part of the NATO ASI Series book series (NSSA, volume 190)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Prologue

    1. Front Matter
      Pages 1-1
  3. General Aspects of Control Theory

    1. Front Matter
      Pages 29-29
    2. Athel Cornish-Bowden
      Pages 31-40
    3. John W. Porteous
      Pages 51-67
    4. Albert K. Groen, Hans V. Westerhoff
      Pages 101-118
  4. Mathematical Aspects of Control Analysis

    1. Front Matter
      Pages 119-119
    2. Jean-Pierre Mazat, Christine Reder, T. Letellier
      Pages 129-138
    3. David A. Fell, Herbert M. Sauro, J. Rankin Small
      Pages 139-148
    4. Enric I. Canela, Marta Cascante, Rafael Franco
      Pages 157-169
  5. Interconvertible Enzymes in Metabolic Control

    1. Front Matter
      Pages 171-171
    2. Albert Goldbeter, Daniel E. Koshland Jr.
      Pages 173-182
    3. P. Boon Chock, Sue Goo Rhee, Earl R. Stadtman
      Pages 183-194
    4. Ronald D. Edstrom, Marilyn H. Meinke, Mary E. Gurnack, David M. Steinhorn, Xiuru Yang, Rui Yang et al.
      Pages 209-217
  6. Methods of Applying Control Analysis to Real Systems

    1. Front Matter
      Pages 219-219
    2. Pedro Mendes, João Moniz Barreto, Ana Vaz Gomes, Ana Ponces Freire
      Pages 221-224
    3. Jan-Hendrik S. Hofmeyr
      Pages 239-248
  7. Channelling of Intermediates and the Time Domain

    1. Front Matter
      Pages 249-249
    2. Henrik Kacser, Herbert M. Sauro, Luis Acerenza
      Pages 251-257
    3. Jacques Ricard, Jean Buc, Nicolas Kellershohn, Jean-Michel Soulié
      Pages 291-296
  8. Experimental Applications

    1. Front Matter
      Pages 315-315
    2. Michael N. Berry, Roland B. Gregory, Anthony R. Grivell, Debra C. Henly, John W. Phillips, Patricia G. Wallace et al.
      Pages 343-350
    3. Richard G. Knowles, Christopher I. Pogson, Mark Salter
      Pages 377-384
    4. Gary K. Smith, Richard G. Knowles, Christopher I. Pogson, Mark Salter, M. Hanlon, R. Mullin
      Pages 385-387
    5. Antony M. Dean
      Pages 389-398
    6. Hans V. Westerhoff, Johanna G. Koster, Marielle van Workum, Kenneth E. Rudd
      Pages 399-412
    7. Daniel E. Atkinson
      Pages 413-427
  9. Back Matter
    Pages 429-454

About this book


THIS BOOK collects together papers given at a NATO Advanced Research Workshop held at Il Ciocco (Lucca), Italy, from the 9th to the 15th April, 1989. It sets out to present the current state of understanding of the principles governing the way fluxes and concentrations are maintained and controlled in metabolic systems. Although this is a topic that has held the interest of biochemists for many years, it is only quite recently that the methods of analysing the kinetics of multi-enzyme pathways developed over the past two decades have come to be widely discussed or applied experimentally. Many biochemists remain sceptical that the new methods offer a real advance (except in complexity) over the landmark discoveries of the 1950s and 1960s relating to inhibition of enzymes at branch-points by the end products of metabolic pathways, and the interpretation of allosteric effects and cooperativity. Even those who have become convinced that the classical ideas provide only the starting point for understanding metabolic control have been by no means unanimous in their assess­ ment of the direction in which one should advance. In this book we have tried to include all of the current points of view, including the view that the classical theories tell us all that we need to know. We have not seen it as our role as editors to paper over the cracks that exist and to pretend that we can speak to the world with one voice.


Amino acid Glutamin Glycogen Nucleotide Purine Termination biosynthesis enzymes gene expression genes metabolic control metabolism

Editors and affiliations

  • Athel Cornish-Bowden
    • 1
  • María Luz Cárdenas
    • 1
  1. 1.Center for Biochemistry and Molecular Biology—CNRSMarseilleFrance

Bibliographic information