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Chemical Carcinogenesis

Models and Mechanisms

  • Francesco Feo
  • Paolo Pani
  • Amedeo Columbano
  • Renato Garcea

Table of contents

  1. Front Matter
    Pages i-xv
  2. Xenobiotics: Metabolism and Interaction with Cellular Macromolecules

    1. Front Matter
      Pages 1-1
    2. Harry V. Gelboin, Frank J. Gonzalez, Sang S. Park, Junji Sagara, Narayana Battula
      Pages 3-15
    3. Fred F. Kadlubar, F. Peter Guengerich, Mary Ann Butler, K. Barry Delclos
      Pages 17-23
    4. William M. Baird, Teresa A. Smolarek, Said M. Sebti, Donna Pruess-Schwartz
      Pages 25-36
    5. Hermann M. Bolt, Hans Peter, Rainer Jäger
      Pages 45-51
    6. Giorgio Cantelli-Forti, G. L. Biagi, P. A. Borea, G. Bronzetti, M. C. Guerra, P. Hrelia et al.
      Pages 53-65
    7. Silvio De Flora, Carmelo F. Cesarone, Carlo Bennicelli, Anna Camoirano, Domizio Serra, Monia Bagnasco et al.
      Pages 75-86
    8. Rosa Pascale, Lucia Daino, Maria E. Ruggiu, Maria G. Vannini, Renato Garcea, Serenella Frassetto et al.
      Pages 87-92
    9. Giorgio Prodi, Annamaria Colacci, Sandro Grilli, Giovanna Lattanzi, Mario Mazzullo, Paola Turina
      Pages 93-102
    10. Jamie R. Milligan, Laura Catz-Biro, Samim Hirani-Hojatti, Michael C. Archer
      Pages 111-117
    11. Marco Presta, Marco Rusnati, Jeanette A. M. Maier, Giovanni Ragnotti
      Pages 129-135
    12. Luisa Airoldi, Marina Bonfanti, Cinzia Magagnotti, Roberto Fanelli
      Pages 137-142
    13. Aldo Tomasi, Emanuele Albano, Barbara Botti, Francesco P. Corongiu, M. Assunta Dessì, Anna Iannone et al.
      Pages 143-151
    14. Alessandro F. Casini, Emilia Maellaro, Alfonso Pompella, Marco Ferrali, Mario Comporti
      Pages 153-163
  3. Developmental Stages of Carcinogenesis

    1. Front Matter
      Pages 165-165
    2. Emmanuel Ferber, Joel Rotstein, Leonard Harris, George Lee, Zhi-Ying Chen
      Pages 167-172
    3. Curtis C. Harris, Roger R. Reddel, Yang Ke, Andrea Pfeiffer, George Mark, Tohru Masui et al.
      Pages 179-183
    4. I. Bernard Weinstein, Gerard M. Housey, Mark D. Johnson, Paul Kirschmeier, Catherine A. O’Brian, Wendy Hsiao et al.
      Pages 185-190
    5. Christine M. Ireland, Eric Hebert, Colin S. Cooper, David H. Phillips
      Pages 191-194
    6. Silvio Parodi, Maurizio Taningher, Patrizia Russo, Paolo Lusuriello, Michael Minks, Rossella Bordone et al.
      Pages 195-202
    7. Snorri S. Thorgeirsson, Peter Nagy, Ritva P. Evarts
      Pages 203-208
    8. Peter Bannasch, Enrique Nogueira, Heide Zerban, Karin Beck, Doris Mayer
      Pages 209-216
    9. Friedrich Marks, Gerhard Fürstenberger, Michael Gschwendt, Michael Rogers, Bärbel Schurich, Bernd Kaina et al.
      Pages 217-234
    10. Ezio Laconi, Pier P. Coni, Giuseppina Pichiri, Prema M. Rao, Srinivasan Rajalakshmi, Dittakavi S. R. Sarma
      Pages 235-241
    11. Gino Malvaldi, Elisabetta Chieli, Adonella Marradi, Michela Saviozzi
      Pages 251-258
    12. Rolf Schulte-Hermann, Wilfried Bursch, Lazlo Fesus, Bettina Kraupp
      Pages 263-274
    13. Wilfried Bursch, Joachim Liehr, David Sirbasku, Rolf Schulte-Hermann
      Pages 275-280
    14. Amedeo Columbano, Giovanna M. Ledda-Columbano, Pierpaolo Coni, Maria G. Ennas, Dittakavi S. R. Sarma, Paolo Pani
      Pages 281-292
    15. Alastair F. Cuthbertson, Derek Higgins, Colin Thomson
      Pages 301-311
    16. Garry J. Smith, Jacqueline M. Bentel, Tarja A. Savolainen, John G. Steel, Christine K. Loo
      Pages 313-315
    17. Shanti Vasudevan, George Lee, Ijaz A. Qureshi, Prema M. Rao, Srinivasan Rajalakshmi, Dittakavi S. R. Sarma
      Pages 317-322
    18. Ulrich Gerbracht, Günter Weiße, Bernd Schlatterer, Manfred Reinacher, Rolf Schulte-Hermann, Erich Eigenbrodt
      Pages 323-335
    19. Rosa Pascale, Saroja Narasimhan, Srinivasan Rajalakshmi
      Pages 337-343
    20. Mario U. Dianzani, Rosa A. Canuto, Margherita Ferro, Anna M. Bassi, Luciana Paradisi, Maria E. Biocca et al.
      Pages 345-359
    21. Arthur G. Schwartz, Laura L. Pashko, Laura A. Hastings, Jeannette H. Whitcomb, Marvin L. Lewbart
      Pages 361-368
    22. Francesco Feo, Renato Garcea, Lucia Daino, Serenella Frassetto, Patrizia Cozzolino, Maria E. Ruggiu et al.
      Pages 369-375
    23. Masahiro Tsutsumi, Seiichi Takahashi, Dai Nakae, Kazumi Shiraiwa, Tetsuo Kinugasa, Kenji Kamino et al.
      Pages 377-387
    24. Véronique Préat, Jean-Claude Pector, Marcel Roberfroid
      Pages 389-397
    25. Hiroyuki Tsuda, Satoshi Uwagawa, Toyohiko Aoki, Shoji Fukushima, Katsumi Imaida, Nobuyuki Ito et al.
      Pages 399-405
    26. Francesco Feo, Renato Garcea, Lucia Daino, Rosa Pascale, Serenella Frassetto, Patrizia Cozzolino et al.
      Pages 407-423
    27. Nobuyuki Ito, Hiroyuki Tsuda, Masae Tatematsu, Katsumi Imaida, Masataka Kagawa, Atsushi Nakamura et al.
      Pages 425-432

About this book

Introduction

About two centuries after the communication by Sir Percival Pott that the "chimney sweeper disease" was a cancer and its suggestion that active compounds of soot were the causative agents, and about one century after the description of urinary bladder cancer in dye workers, an enormous number of substances have been synthesized and have probably come into contact with man. Research in cancer prevention is of primary importance, and may receive continuous support from new discoveries on cancer etiology and pathogenesis. If one accepts the multistage model of chemical carcinogenesis, one has also to accept that many events occur between the contact of carcino­ genic compounds and their specific targets and the development of a clinically recognizable neoplasm. Thus, animal studies become essential to elucidate the different steps by which chemical carcinogens induce neoplasia. The analysis of these steps and the comparative evaluation of experimental models is essential to an understanding of pathogenesis.

Keywords

apoptosis cancer carcinogenesis cell cell culture etiology hormones liver liver tumor mutagen pathogenesis prevention surgery tumor tumorigenesis

Editors and affiliations

  • Francesco Feo
    • 1
  • Paolo Pani
    • 2
  • Amedeo Columbano
    • 2
  • Renato Garcea
    • 1
  1. 1.University of SassariSassariItaly
  2. 2.University of CagliariCagliariItaly

Bibliographic information