Cellular and Molecular Biology of Intermediate Filaments

  • Robert D. Goldman
  • Peter M. Steinert

Table of contents

  1. Front Matter
    Pages i-xix
  2. The Subcellular Organization of Intermediate Filaments

    1. Front Matter
      Pages 1-1
    2. Robert D. Goldman, Robert V. Zackroff, Peter M. Steinert
      Pages 3-17
    3. Marvin H. Stromer
      Pages 19-36
    4. P. A. M. Eagles, H. C. Pant, H. Gainer
      Pages 37-94
    5. George N. Dessev
      Pages 129-145
    6. Kathleen J. Green, Jonathan C. R. Jones
      Pages 147-171
  3. The Structure of Intermediate Filaments

    1. Front Matter
      Pages 173-173
    2. R. D. B. Fraser, T. P. MacRae, David A. D. Parry
      Pages 205-231
    3. Alasdair C. Steven
      Pages 233-263
  4. Differential Expression of Intermediate Filament Genes

    1. Front Matter
      Pages 265-265
    2. Barry C. Powell, George E. Rogers
      Pages 267-300
    3. W. Michael O’Guin, Alexander Schermer, Marion Lynch, Tung-Tien Sun
      Pages 301-334
    4. Thomas D. Sargent, Erzsebet Jonas, Milan Jamrich, George S. Michaels, Seiji Miyatani, Jeffrey A. Winkles et al.
      Pages 335-344
    5. Peter M. Steinert, Dennis R. Roop
      Pages 353-367
  5. Accessory Proteins Involved in Regulating the Organization of Intermediate Filaments

    1. Front Matter
      Pages 369-369
    2. Hsi-Yuan Yang, Norman Lieska, Robert D. Goldman
      Pages 371-391
    3. Beverly A. Dale, Katheryn A. Resing, Paul V. Haydock
      Pages 393-412
  6. Pathological Conditions Relating to Intermediate Filaments

    1. Front Matter
      Pages 413-413
    2. Michael L. Shelanski, Carol M. Troy
      Pages 451-465
  7. Back Matter
    Pages 467-479

About this book


Research activity on intermediate filaments (IF) has increased dramatically over the past decade. For the most part, this surge of interest is due to their identification as ubiquitous constituents of the cytoskeleton and karyoskeleton (nuclear matrix) of eukaryotic cells and the fact that we know very little regarding their functions. In sharp contrast to the other major cytoskeletal systems, microfilaments and microtubules, IF exhibit a high degree of heterogeneity with regard to their protein subunit composition. Indeed, one can only marvel at the number of different IF polypeptides, their associated proteins (IFAP) and, consequently, the number of genes involved in encoding the multiple constituents of the various IF networks found in different cell types. The chapters in this book demonstrate how various experimental approaches involv­ ing cellular, molecular, biochemical, and immunological methods have been utilized to generate information regarding the structure and function of IF. To this end, we have gathered together chapters from experts in the major fields of IF research. In each chapter, the authors have combined reviews of the available scientific literature with their own ideas on current and future directions for IF research. The chapters have been divided into five major sections which are concerned with the subcellular organization of IF, the molecular structure of IF, the differential expression of IF genes, descriptions of associ­ ated proteins involved in the intracellular organization of IF, and finally an analysis of the changes seen in IF in pathological conditions.


Polypeptide biology cell nucleus development evolution genes molecular biology protein proteins

Editors and affiliations

  • Robert D. Goldman
    • 1
  • Peter M. Steinert
    • 2
  1. 1.Northwestern University Medical SchoolChicagoUSA
  2. 2.National Cancer InstituteNational Institutes of HealthBethesdaUSA

Bibliographic information