Basophil and Mast Cell Degranulation and Recovery

  • Ann M. Dvorak

Part of the Blood Cell Biochemistry book series (BLBI, volume 4)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Ann M. Dvorak
    Pages 1-2
  3. Ann M. Dvorak
    Pages 3-25
  4. Ann M. Dvorak
    Pages 101-275
  5. Ann M. Dvorak
    Pages 369-370
  6. Back Matter
    Pages 371-415

About this book


Basophils and mast cells are similar but unique secretory cells with a well-documented role in immediate-hypersensitivity reactions. The presence of these cells in various cell­ mediated hypersensitivity reactions, in tissues of multiple diseases, and as a component of the host reaction to injury and repair in numerous circumstances is well known. Release of stored and newly generated mediators of inflammation from basophils and mast cells contributes to the cascade of pathogenetic events in circumstances under which these release reactions occur. Despite insights acquired through studies of these pathologic events, the role of basophils and mast cells and their secretory products in health is not known. In this book, I review much of the structural information regarding basophils and mast cells of multiple species. Ultrastructural studies of rat mast cells historically precede and quantitatively exceed similar studies of basophils and mast cells of other species. Therefore, I first review these background studies as an entity. Then I discuss the contents of two prominent organelles-granules and lipid bodies-in basophils and mast cells of several species. The ultrastructural morphology of basophils and mast cells in three species is presented in detail to establish appropriate guidelines for their recognition and to provide general rules for analysis which are appropriate for the identification of these cells in other species as well.


Lipid Organelle cell diseases inflammation tissue

Authors and affiliations

  • Ann M. Dvorak
    • 1
  1. 1.Beth Israel Hospital and Harvard Medical SchoolBostonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1991
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-9527-1
  • Online ISBN 978-1-4757-9525-7
  • Series Print ISSN 1078-0491
  • Buy this book on publisher's site