• Enrico Mihich
  • Robert T. Schimke

Part of the Pezcoller Foundation Symposia book series (PFSO, volume 5)

Table of contents

  1. Front Matter
    Pages i-x
  2. David S. Papermaster, Izhak Nir
    Pages 15-29
  3. Eyal Gottlieb, Rebecca Haffner, Elisheva Yonish-Rouach, Thomas von Ruden, Erwin Wagner, Moshe Oren
    Pages 31-45
  4. Eileen White, Lakshmi Rao, Shiun-Kwei Chiou, Ching-Chun Tseng, Peter Sabbatini, Michelle Gonzalez et al.
    Pages 47-62
  5. Gerard Evan, Trevor Littlewood, David Hancock, Martin Bennett, Elizabeth Harrington, Abdallah Fanidi
    Pages 63-84
  6. John L. Cleveland, David S. Askew, Concha Bello-Fernandez, Graham Packham
    Pages 85-96
  7. Pierluigi Nicotera, Boris Zhivotovsky, Giorgio Bellomo, Sten Orrenius
    Pages 97-115
  8. Yuzo Furuya, Richard S. Berges, Per Lundmo, John T. Isaacs
    Pages 137-155
  9. David M. Hockenbery
    Pages 157-177
  10. Melanie S. Vacchio, Yili Yang, Jonathan D. Ashwell
    Pages 179-200
  11. Tadatsugu Taniguchi, Hisashi Harada, Motoo Kitagawa, Nobuyuki Tanaka, Nobumasa Watanabe, Tohru Kimura
    Pages 201-212
  12. Douglas R. Green, Yufang Shi, Jaqueline Glynn, Artin Mahboubi, Rona J. Mogil
    Pages 213-222
  13. Steven W. Sherwood, Robert T. Schimke
    Pages 223-236
  14. Alan Eastman, Michael A. Barry, Catherine Demarcq, Jinfang Li, Jason E. Reynolds
    Pages 249-264
  15. Back Matter
    Pages 265-272

About this book


The fifth Annual Pezcoller Symposium entitled, Apoptosis, was held in Trento, Italy, June 9-1I, 1993 and was focused on the specific phenomena leading to Programmed Cell Death (PCD) or Apoptosis, and the mechanisms involved. With presentations at the cutting edge of progress and stimulating discussions, this Symposium addressed the genetics and molecular mechanisms determining PCD and the role of this suicidal process in cancer and the immune system. The functions of pS3, c myc and bel 2 in affecting apoptosis in different cell types and the role of ions and intracellular pH changes and that of intranuelear endonueleases are given particular emphasis as are the effects of anticancer agents, hormone imbalances and growth factors. The role of pS3, a tumor suppressor gene, in inducing PCD is discussed in detail as pertinent to hematological and non-hernatological tumors. The requirement of pS3 for the induction ofapoptosis by ionizing radiation or adenovirus oncoproteins is outlined. Decision points during the cell cyele affecting the cascade ofevents leading to PCD are discussed as is their role as "switches" under the control of c-myc and bel-2 proteins or the influence of cyele specific drugs. The concurrent requirement of multiple signals in determining apoptosis is emphasized. The examples of the role of PCD in the regulation of hematopoiesis, and in the generation of antigen-specific immune repertoire are illustrated.


Antigen DNA apoptosis cancer cell cell death cell growth gene genetics growth molecular mechanisms programmed cell death proteins regulation transcription

Editors and affiliations

  • Enrico Mihich
    • 1
  • Robert T. Schimke
    • 2
  1. 1.Roswell Park Cancer InstituteBuffaloUSA
  2. 2.Stanford UniversityStanfordUSA

Bibliographic information