Alcohol and the Brain

Chronic Effects

  • Ralph E. Tarter
  • David H. van Thiel

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Basic Research

    1. Front Matter
      Pages 1-1
    2. Gerhard Freund
      Pages 3-17
    3. Paula L. Hoffman, Boris Tabakoff
      Pages 19-68
    4. David H. van Thiel, Judith S. Gavaler
      Pages 69-79
    5. David R. Antonow, Craig J. McClain
      Pages 81-120
    6. Daniel F. Schafer
      Pages 121-137
    7. Bernice Porjesz, Henri Begleiter
      Pages 139-182
    8. D. Adrian Wilkinson
      Pages 183-215
    9. Ralph E. Tarter, Kathleen L. Edwards
      Pages 217-242
  3. Clinical Issues

    1. Front Matter
      Pages 243-243
    2. Gerald Goldstein
      Pages 283-294
    3. David A. Greenberg, Ivan Diamond
      Pages 295-314
  4. Back Matter
    Pages 339-349

About this book

Introduction

Chronic and excessive alcohol consumption disrupts a number of biologic sys­ tems. Central nervous system pathology, associated with long-standing alcohol ingestion, has particularly deleterious consequences to the individual. Compro­ mising brain functional integrity ultimately militates against psychosocial ad­ justment, and this process is inevitably reflected as a substantial economic loss to society in the form of costs for providing medical and social services, as well as disability and absenteeism from work. This book marshals the literature pertinent to the effects of chronic alcohol abuse on brain structure and functioning. The material is divided into two parts: basic research and clinical issues. In the first section, the manifest neurologic consequences are described across the different levels of biologic organization, these being brain morphology, neurochemistry, neurophysiology, and neuro­ psychology. In recognition of the multifactorial etiology of alcohol-related brain pathology, the influence and role of hepatic, endocrine, and nutritional factors are also examined. The second section addresses clinical syndromes and dis­ orders. It will be noted that evidence accrued from recent research suggests that neurologic disturbances may actually antedate the onset of drinking in some alcoholics. Other clinically important issues discussed are the effects of alcohol on neurologic development, aging, and dementia. The book concludes with a discussion of the alcohol withdrawal syndrome, its mechanisms and manifes­ tations. A fundamental objective of the editors was to illustrate that the consequences of chronic alcohol excess can be comprehensively understood within the per­ spective of interrelated hierarchical systems of brain organization.

Keywords

Nervous System Syndrom biochemistry dementia neurophysiology neuropsychology physiology

Editors and affiliations

  • Ralph E. Tarter
    • 1
  • David H. van Thiel
    • 2
  1. 1.Department of Psychiatry, Western Psychiatric Institute and ClinicUniversity of Pittsburgh School of MedicinePittsburghUSA
  2. 2.Department of Medicine, Division of GastroenterologyUniversity of Pittsburgh School of MedicinePittsburghUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4757-9134-1
  • Copyright Information Springer-Verlag US 1985
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-9136-5
  • Online ISBN 978-1-4757-9134-1
  • About this book