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Randomised Controlled Clinical Trials

  • Christopher J. Bulpitt

Part of the Developments in Biostatistics and Epidemiology book series (DBEP, volume 1)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Christopher J. Bulpitt
    Pages 1-4
  3. Christopher J. Bulpitt
    Pages 5-11
  4. Christopher J. Bulpitt
    Pages 12-27
  5. Christopher J. Bulpitt
    Pages 28-34
  6. Christopher J. Bulpitt
    Pages 35-38
  7. Christopher J. Bulpitt
    Pages 39-43
  8. Christopher J. Bulpitt
    Pages 56-79
  9. Christopher J. Bulpitt
    Pages 80-95
  10. Christopher J. Bulpitt
    Pages 96-117
  11. Christopher J. Bulpitt
    Pages 118-135
  12. Christopher J. Bulpitt
    Pages 136-143
  13. Christopher J. Bulpitt
    Pages 144-156
  14. Christopher J. Bulpitt
    Pages 157-178
  15. Christopher J. Bulpitt
    Pages 179-193
  16. Christopher J. Bulpitt
    Pages 194-208
  17. Christopher J. Bulpitt
    Pages 209-213
  18. Christopher J. Bulpitt
    Pages 214-220
  19. Christopher J. Bulpitt
    Pages 244-254
  20. Back Matter
    Pages 255-262

About this book

Introduction

Bradford Hill has defined a clinical trial as "A carefully and ethically designed experiment with the aim of answering some precisely framed question" [1]. This definition specifies a careful design and requires the provision of adequate controls. Random allocation of treatments to subjects is important to ensure is entitled that the treated and control groups are similar. Therefore this book Randomised Controlled Clinical Trials. We can define a randomised controlled trial by rewriting Bradford Hill's definition as follows, "A carefully and ethi­ cally designed experiment which includes the provision of adequate and ap­ propriate controls by a process of randomisation, so that precisely framed questions can be answered. " I am a firm advocate ofRandomised Controlled Clinical Trials but intend to give a balanced view of the advantages and disadvantages of these ethical experiments. This book is directed primarily at the medical research worker, although certain chapters may find a wider application. When discussing a randomised controlled trial, it is neither practicable nor desirable to divorce theory from practice, however the first ten chapters con­ centrate mainly on theory, and the remainder focus on practice. The segment on trial design is followed by sections on writing the protocol, designing the forms, conducting the trial, and analysing the results. This book is meant to serve both as a reference manual and a practical guide to the design and performance of a trial.

Keywords

experiment

Authors and affiliations

  • Christopher J. Bulpitt
    • 1
    • 2
    • 3
  1. 1.Department of Medical Statistics and EpidemiologyLondon School of Hygiene and Tropical MedicineLondonUK
  2. 2.Royal Postgraduate Medical SchoolLondonUK
  3. 3.Hammersmith HospitalLondonUK

Bibliographic information