Breast Cancer:Advances in Research and Treatment, Vol. 2: Experimental Biology

  • William L. McGuire

Table of contents

  1. Front Matter
    Pages i-xix
  2. Albert Segaloff
    Pages 1-22
  3. Jeffrey Schlom, David Colcher, William Drohan, Donald Kufe, Yoshio A. Teramoto
    Pages 23-46
  4. Daniel Medina
    Pages 47-102
  5. C. Kent Osborne, Marc E. Lippman
    Pages 103-154
  6. Kathryn B. Horwitz, William L. McGuire
    Pages 155-204
  7. Ronald B. Herberman
    Pages 205-257
  8. Lewis M. Schiffer
    Pages 259-282
  9. Arthur E. Bogden
    Pages 283-336
  10. Back Matter
    Pages 395-407

About this book


Breast cancer continues to be the focus of intense basic and clinical research. In Valurne 1 of this series we dealt exclusively with topics concerned with therapy. In the present Valurne 2, we turn our attention to the experimental biology which is the foundation for our understand­ ing of problems concerned with breast cancer etiology, mechanisms of hormone action, cell kinetics, experimental chemotherapy, and markers of tumor burden. The contributors to the volume are all noted scholars who are personally investigating these problems. The first chapter addresses the question, do hormones cause breast cancer? Segaloff provides us with a rational up-to-date overview of the existing data. He concludes that hormones by themselves are not tumor initiators but rather alter the hast environment so that other carcinogens are effective. lt is pointed out that the selection of the modeltest system is critical; one can almost assure any desired result by choosing an ap­ propriately biased test system. The question of the role of viruses in the etiology of human breast cancer remains unanswered despite elegant studies in mause systems.


breast cancer cancer cell chemotherapy hormones tumor

Editors and affiliations

  • William L. McGuire
    • 1
  1. 1.University of Texas Health Science CenterSan AntonioUSA

Bibliographic information