Cardiac Ischemia: From Injury to Protection

  • Bohuslav Ošt’ádal
  • František Kolář

Part of the Basic Science for the Cardiologist book series (BASC, volume 4)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Bohuslav Ošt’ádal, František Kolář
    Pages 1-44
  3. Bohuslav Ošt’ádal, František Kolář
    Pages 45-63
  4. Bohuslav Ošt’ádal, František Kolář
    Pages 65-79
  5. Bohuslav Ošt’ádal, František Kolář
    Pages 81-87
  6. Bohuslav Ošt’ádal, František Kolář
    Pages 89-133
  7. Bohuslav Ošt’ádal, František Kolář
    Pages 135-148
  8. Back Matter
    Pages 149-173

About this book

Introduction

Cardiac Ischemia: From Injury to Protection has been divided into six parts. The first part describes the differences between hypoxia and ischemia, animal models, the effects of ischemia on myocardial function and metabolism, and the electrophysiological consequences of ischemia. The second part deals with the mechanisms of cardiomyocyte death in ischemia, structural aspects of irreversible ischemic injury, necrosis and apoptosis of cardiac cells, the role of calcium, and the concept of calcium antagonism. The third chapter is a brief description of reperfusion injury, its clinical relevance, and possible prevention. The fourth part summarizes changes in myocardial vasculature during ischemia and reperfusion. The fifth part is the survey of two main possibilities for increasing cardiac resistance to ischemia and hypoxia, i.e. long-lasting adaptation to chronic hypoxia and short-lasting preconditioning. The last part of the book deals with comparative and ontogenetic aspects of cardiac sensitivity to oxygen deprivation; this chapter also summarizes the ontogenetic differences and limitations in endogenous and exogenous protection of the ischemic/hypoxic heart.

Keywords

adaptation apoptosis calcium cells death development heart hypoxia metabolism necrosis prevention resistance

Authors and affiliations

  • Bohuslav Ošt’ádal
    • 1
  • František Kolář
    • 1
  1. 1.Department of Developmental Cardiology Institute of PhysiologyAcademy of Sciences of the Czech RepublicPragueCzech

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4757-3025-8
  • Copyright Information Springer-Verlag US 1999
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4419-5105-2
  • Online ISBN 978-1-4757-3025-8
  • Series Print ISSN 1566-0753
  • About this book