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Cytochrome P450

Structure, Mechanism, and Biochemistry

  • Paul R. Ortiz de Montellano

Table of contents

  1. Front Matter
    Pages i-xii
  2. Model Systems

    1. Front Matter
      Pages 1-1
    2. John T. Groves, Yuan-Zhang Han
      Pages 3-48
    3. Lawrence J. Marnett, Todd A. Kennedy
      Pages 49-80
  3. Structurally Defined Bacterial Enzymes

    1. Front Matter
      Pages 81-81
    2. Ernest J. Mueller, Paul J. Loida, Stephen G. Sligar
      Pages 83-124
    3. Thomas L. Poulos, Jill Cupp-Vickery, Huiying Li
      Pages 125-150
    4. Julian A. Peterson, Sandra E. Graham-Lorence
      Pages 151-180
  4. Structures and Mechanisms of Membrane-Bound P450 Enzymes

    1. Front Matter
      Pages 181-181
    2. Claes Von Wachenfeldt, Eric F. Johnson
      Pages 183-223
    3. Henry W. Strobel, Anne V. Hodgson, Sijiu Shen
      Pages 225-244
    4. Paul R. Ortiz de Montellano
      Pages 245-303
    5. Paul R. Ortiz de Montellano, Maria Almira Correia
      Pages 305-364
  5. Regulatory Mechanisms and Physiological Roles of Cytochrome P450

    1. Front Matter
      Pages 365-365
    2. James P. Whitlock Jr., Michael S. Denison
      Pages 367-390
    3. David J. Waxman, Thomas K. H. Chang
      Pages 391-417
    4. Norio Kagawa, Michael R. Waterman
      Pages 419-442
    5. Jorge H. Capdevila, Darryl Zeldin, Keiko Makita, Armando Karara, John R. Falck
      Pages 443-471
    6. F. Peter Guengerich
      Pages 473-535
  6. Back Matter
    Pages 575-652

About this book

Introduction

In the ten years that have elapsed since the first edition of this book went to press, the cytochrome P450 field has completed the transition to a discipline in which structure and mechanism, even regulation and biological function, are dealt with in molecular terms. The twin forces that have propelled this remarkable progress have been the widespread adoption of molecular biological approaches and the successful application of modem structural techniques. Only a few P450 primary sequences were available in 1985, whereas hundreds of P450 sequences are now available. Site-specific mutagenesis was then mostly a proverbial gleam in the eye of the P450 community, but it is now a standard technique in the research repertoire. The first crystal structure of a cytochrome P450 enzyme had just been solved in 1985 and appeared on the cover of the first edition. Today, the high-reso­ lution crystal structures of four soluble bacterial P450 enzymes are available and the race is on to develop approaches that will permit us to determine the structures of the membrane-bound forms of the enzyme. The past ten years has seen phenomenal progress­ let us hope that the next ten will prove equally exciting. The book is informally divided into four sections. In order to hold the book close to the advancing front of research, some of the chapter topics from the first edition have been dropped to make room for new or expanded topics.

Keywords

NADPH Oxidation biochemistry cytochrome P450 enzymes metabolism proteins

Editors and affiliations

  • Paul R. Ortiz de Montellano
    • 1
  1. 1.Department of Pharmaceutical Chemistry, School of PharmacyUniversity of California, San FranciscoSan FranciscoUSA

Bibliographic information