The Guanine — Nucleotide Binding Proteins

Common Structural and Functional Properties

  • L. Bosch
  • B. Kraal
  • A. Parmeggiani

Table of contents

  1. Front Matter
    Pages i-x
  2. Three-Dimensional Structures and Consensus Sequence Elements

    1. Front Matter
      Pages 1-1
    2. Frances Jurnak, Michelle Nelson, Marilyn Yoder, Susan Heffron, Suet Miu
      Pages 15-25
    3. A. M. de Vos, L. Tong, M. V. Milburn, P. M. Matias, S.-H. Kim
      Pages 27-34
    4. Thomas E. Dever, William C. Merrick
      Pages 35-48
  3. Structure, Function and Genetics of Translational Factors

    1. Front Matter
      Pages 49-49
    2. Diarmaid Hughes, C. G. Kurland
      Pages 51-56
    3. Pieter H. Anborgh, Robbert H. Cool, Eric Jacquet, Michael Jensen, Giuseppe Parlato, Andrea Parmeggiani
      Pages 67-75
    4. Yu-Wen Hwang, Frances Jurnak, David L. Miller
      Pages 77-85
    5. John W. B. Hershey, Vinay K. Pathak, Heidemarie Ernst, Markus Hümbelin, Randal J. Kaufman
      Pages 143-150
  4. Structure, Function and Genetics of ras Proteins

    1. Front Matter
      Pages 151-151
    2. P. Chardin, N. Touchot, A. Zahraoui, V. Pizon, I. Lerosey, B. Olofsson et al.
      Pages 153-163
    3. Berthe M. Willumsen, Hedy Adari, Ke Zhang, Alex G. Papageorge, James C. Stone, Frank McCormick et al.
      Pages 165-177

About this book

Introduction

This volume contains the proceedings of the EMBO-NATO-CEC Advanced Research Workshop on "Guanine-nucleotide binding proteins. Common structural and functional properties", which was held in Renesse, The Netherlands, August 6-11, 1988. The transmission of information is one of the most important processes in cellular life and involves the most diverse physiological functions. The cellular membrane, as the obligatory target for external signals, harbours complex pathways transducing the signals from the receptors of the external stimuli to the cytoplasmic effector. Heterotrimeric proteins are fundamental components of these pathways. Other proteins that are monomeric may be found associated with the membrane or in soluble form in the cytoplasm, and' can also function in signal transduction. Intracellular transmission of signals may proceed in an analogous fashion, protein synthesis being a well-known example. It is one of the most remarkable and puzzling observations of recent years that all of these proteins share common properties, both functionally and structurally. The ir primary structures show pronounced s imilari ties, in most cases concentrated in the NH2-terminal portion of the molecule. They all bind guanine nucleotides (hence the general name of G-proteins) and are GTPases, a crucial enzymatic activity, since it converts the active complex induced by GTP into the inactive one induced by GDP. Consensus sequences have been ident if ied as responsable for interact ing with the different parts of the guanine nucleotide.

Keywords

Nucleotide primary structure protein protein synthesis proteins receptor synthesis

Editors and affiliations

  • L. Bosch
    • 1
  • B. Kraal
    • 1
  • A. Parmeggiani
    • 2
  1. 1.Leiden UniversityLeidenThe Netherlands
  2. 2.Ecole PolytechniquePalaiseauFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4757-2037-2
  • Copyright Information Springer-Verlag US 1989
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-2039-6
  • Online ISBN 978-1-4757-2037-2
  • About this book