Purine Metabolism in Man

Biochemistry and Pharmacology of Uric Acid Metabolism

  • Oded Sperling
  • Andre De Vries
  • James B. Wyngaarden

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Gout

    1. Front Matter
      Pages xxiii-xxiii
    2. Etiology of Purine Overproduction in Gout

    3. Effects of Diet, Weight, and Stress on Purine Metabolism

      1. J. A. Dosman, J. C. Crawhall, G. A. Klassen
        Pages 423-427
      2. N. Zöllner, A. Griebsch
        Pages 435-442
    4. Relationship Between Carbohydrate, Lipid, and Purine Metabolism

    5. Renal Disease and Uric Acid Lithiasis in Urate Overproduction

      1. D. A. Farebrother, P. J. Hatfield, H. A. Simonds, J. S. Cameron, A. S. Jones, A. Cadenhead
        Pages 523-534
    6. Urate Deposition in Tissue

      1. R. Bluestone, J. R. Klinenberg, J. Waisman, L. S. Goldberg
        Pages 551-554
    7. Urate Binding to Plasma Proteins

      1. James R. Klinenberg, Rodney Bluestone, David Campion, Michael Whitehouse
        Pages 557-566
  3. Pharmacology

    1. Front Matter
      Pages 567-567
    2. Allopurinol and Thiopurinol in the Treatment of Gout

      1. Gerald P. Rodnan, James A. Robin, Sanford F. Tolchin
        Pages 571-575
      2. J. T. Scott, W. Y. Loebl
        Pages 577-579
      3. R. Grahame, H. A. Simmonds, A. Cadenhead, B. M. Dean
        Pages 597-605
    3. Effects of Allopurinol and Its Metabolities on Purine and Pyrimidine Metabolism

    4. Adenine Therapy in the Lesch-Nyhan Syndrome

      1. Mario Ceccarelli, Maria Laura Ciompi, Giampiero Pasero
        Pages 671-675
      2. Simonetta Nissim, Maria Laura Ciompi, Laura Barzan, Giampiero Pasero
        Pages 677-679
    5. Benzbromaron, 3-Hydroxy Purines, 3-Butylazathioprine

      1. J. S. Cameron, H. A. Simmonds, P. J. Hatfield, A. S. Jones, A. Cadenhead
        Pages 691-692
      2. A. H. Chalmers, A. W. Murray, P. Verakalasa
        Pages 699-704
  4. Renal Handling of Urate

    1. Front Matter
      Pages 705-705
    2. Hypouricemia and the Effect of Pyrazinamide on Renal Urate Excretion

      1. C. M. Ramsdell, W. N. Kelley
        Pages 709-716
      2. O. Sperling, A. Weinberger, I. Oliver, U. A. Liberman, A. de Vries
        Pages 717-721
      3. Peter A. Simkin, Maurice D. Skeith, L. A. Healey
        Pages 723-728

About this book


Gout and urie acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of urie acid excretion, although still posing difficult problems, appears to approach clari­ fication.


biochemistry DNA enzymes Fructose Glutamin metabolism mutation Nucleotide pharmacology protein Purine Pyrimidine RNA synthesis Xanthin

Editors and affiliations

  • Oded Sperling
    • 1
  • Andre De Vries
    • 1
  • James B. Wyngaarden
    • 2
  1. 1.Division of Metabolic Disease, Rogoff-Wellcome Medical Research InstituteBeilinson HospitalPetah-TikvaIsrael
  2. 2.Department of MedicineDuke University Medical CenterDurhamUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 1974
  • Publisher Name Springer, New York, NY
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-1435-7
  • Online ISBN 978-1-4757-1433-3
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site