Contemporary Topics in Molecular Immunology

  • Ralph A. Reisfeld
  • F. P. Inman

Part of the Contemporary Topics in Molecular Immunology book series (CTI)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Gerrie A. Leslie, Louis N. Martin
    Pages 1-49
  3. Allen B. Edmundson, Kathryn R. Ely, Enrique E. Abola
    Pages 95-118
  4. Tony E. Hugli
    Pages 181-214
  5. Leon Wofsy, Claudia Henry, Salvatore Cammisuli
    Pages 215-237
  6. Soldano Ferrone, James P. Allison, Michele A. Pellegrino
    Pages 239-281
  7. Fiona Hunter, John E. Mole, J. Claude Bennett
    Pages 283-317
  8. Back Matter
    Pages 415-425

About this book


New information is developing so rapidly in the entire field of immunology that one is unable to remain abreast of all advancing fronts. In many cases, consider­ able information has accumulated as the result of the efforts of many investigators, but the conclusions from the various laboratories have not been summarized recently in a comprehensible manner. One such situation has to do with work on IgD. An up-to-date report on this immunoglobulin was included in Volume 10f this series, but since that time there has been considerable progress in the deter­ mination of its structure and function. In the present volume Leslie and Martin have reviewed the accomplishments of recent years and the problems remaining to be solved. New information regarding the concentration of IgD in body fluids in normal and disease states is presented. Studies of the ontogeny of surface IgD in animals are described, and the fmdings imply that it may be important in the primary immune response. The role of IgD on lymphocyte surfaces is thoroughly discussed especially in terms of stimulating or suppressive combinations of signals delivered to the lymphocyte by agents which bind or alter the surface rt:ceptors. The authors conclude by proposing a model for plasma-cell differentiation which accounts fo~ the existence of triple Ig-bearing cells, many IgM-IgD-bearing cells, and the low percentage of cells bearing a single isotype. Sometimes the serum of an individual contains abnormally large amounts of two distinct, homogeneous populations of immunoglobulins.


immune response immunoglobulin immunology

Editors and affiliations

  • Ralph A. Reisfeld
    • 1
  • F. P. Inman
    • 2
  1. 1.Department of Molecular ImmunologyScripps Clinic and Research FoundationLa JollaUSA
  2. 2.Department of BiochemistryEast Tennessee State UniversityJohnson CityUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 1978
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-0781-6
  • Online ISBN 978-1-4757-0779-3
  • Buy this book on publisher's site