Historical, Biological, Biochemical, and Clinical Aspects of the Naturally Occurring Guanidino Compounds

  • Akitane Mori
  • B. D. Cohen
  • A. Lowenthal

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Analytical Method for Guanidino Compounds

    1. Front Matter
      Pages 1-1
    2. Sakae Higashidate, Tetsuya Maekubo, Muneo Saito, Masaaki Senda, Tadao Hoshino
      Pages 3-13
    3. Yiau-Lin Huang, Masaaki Kai, Yosuke Ohkura
      Pages 15-31
    4. Motoo Nakajima, Kazuo Nakamura, Yoshio Shirokane
      Pages 39-46
  3. Metabolism of Guanidino Compound in Normal and Abnormal Organs, and in Metabolic Diseases

    1. Front Matter
      Pages 47-47
    2. Yoko Watanabe, Shoichiro Shindo, Akitane Mori
      Pages 49-58
    3. Yoko Watanabe, Takashi Kadoya, Masayoshi Fukui, Rei Edamatsu, Akitane Mori, Sonoko Seki
      Pages 59-69
    4. Shoichiro Shindo, Akitane Mori
      Pages 71-81
    5. Kazumasa Aoyagi, Shoji Ohba, Mitsuhiro Miyazaki, Sohji Nagase, Satomi Iida, Mitsuharu Narita et al.
      Pages 83-92
    6. Kazumasa Aoyagi, Shoji Ohba, Mitsuhiro Miyazaki, Sohji Nagase, Satomi Iida, Mitsuharu Narita et al.
      Pages 93-103
    7. Hiroaki Muramoto, Yohei Tofuku, Mitsuhiko Kuroda, Ryoyu Takeda
      Pages 105-112
    8. K. C. Chitra, K. S. Swami, K. S. Jagannatha Rao
      Pages 113-118
    9. V. Mohanachari, K. Satyavelu Reddy, K. Indira, K. S. Swami
      Pages 119-124
    10. Harini Patel, Burton D. Cohen
      Pages 135-144
    11. Takeyori Saheki, Mariko Sase, Kyoko Nakano, Yukio Yagi
      Pages 149-158

About this book


In 1978, we had the first research meeting of guanidine compound analysis in Okayama, Japan. The purpose of the meeting was to standardize the methods of analyzing guanidino compounds, because the analytic methods, even, for example, that of normal plasma, were quite different from laboratory to laboratory at that time. More than ten laboratories joined in this research project. Thereafter, the purpose of the annual meetings was extended to cover general biochemistry of guanidino compounds, and every meeting has served to promote our mutual growth and progress. The last meeting of the Japan Guanidino Compounds Research Association in 1982 brought together more than 80 members, and about 30 papers were presented there. This, the 6th annual meeting, brings the International Symposium on Guani­ dino Compounds here to Tokyo. Recently, many scientists are engaged in the research of guanidine compounds, especially in the field of clinical bio­ chemistry. I am sure that the observation of guanidinosuccinic acid in the urine of uremic patients by Dr. Cohen's research group in 1963 ignited the recent exploration of the role of guanidino compounds in renal diseases. The study of guanidino compounds does, however, have a long history. The first knowledge of guanidine was obtained by Strecker in 1861 (Annalen der Chemie und Pharmacie, 118, 151- 177, 1981).


Plasma alcohol biochemistry chemistry growth kidney metabolism paper pharmacology protein protein synthesis quantitative analysis synthesis

Editors and affiliations

  • Akitane Mori
    • 1
  • B. D. Cohen
    • 2
  • A. Lowenthal
    • 3
  1. 1.Inst. for NeurobiologyOkayama University Medical SchoolOkayama 700Japan
  2. 2.The Bronx Lebanon Hospital CenterBronxUSA
  3. 3.Laboratory of Neurochemistry, Born-Bunge FoundationUniversitaire Instelling AntwerpenWilrijkBelgium

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1985
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-0754-0
  • Online ISBN 978-1-4757-0752-6
  • About this book