Mass Spectrometry in Biotechnological Process Analysis and Control

  • Elmar Heinzle
  • Matthias Reuss

Table of contents

  1. Front Matter
    Pages i-xi
  2. Introduction

    1. Elmar Heinzle, Matthias Reuss
      Pages 1-6
  3. Instrumentation and Gas Analysis

  4. Membrane Inlet Systems

    1. M. Griot, E. Heinzle, I. J. Dunn, J. R. Bourne
      Pages 75-90
    2. D. Lloyd, A. G. Williams, K. Hillman, T. N. Whitmore
      Pages 91-103
    3. M. Reuss
      Pages 105-114
  5. Applications and Computer Control

    1. S. Bohatka, J. Szilagyi, G. Langer
      Pages 115-123
    2. A. Luebbert, S. Froehlich, K. Schuegerl
      Pages 125-142
    3. Anthony O’L. Richards, Stephen H. Stanley, Howard Dalton
      Pages 163-177
  6. Pyrolysis-MS and HPLC-MS Interfacing

    1. Jaap J. Boon, B. Brandt-de Boer, G. B. Eijkel, Elly Vlegels, Lolke Sijtsma, Jan T. M. Wouters
      Pages 187-208
    2. E. P. Sandmeier, J. Keller, E. Heinzle, I. J. Dunn, J. R. Bourne
      Pages 209-215
    3. E. P. Lankmayr
      Pages 217-223
  7. Back Matter
    Pages 231-241

About this book


This book is based on the contributions to the IFAC-Workshop "Mass Spectro­ metry in Biotechnological Process Analysis and Control" held in Graz, Austria from 23 to 24 October 1986. The idea to organize this workshop and further to prepare these proceedings was stimulated by the following facts. Biotechnological processes urgently need better on-line instrumentation. Mass spectrometry (MS) offers a great potential to especially analyse gases and volatile compounds. It is, however, considered that this potential by far is not exhausted. The main reason for this is that MS often still is considered to be a very expensive technique requiring the permanent attention of a MS expert. In addition methods have not yet been developed to a user friendly state. On-line MS-methods are available to a certain extent, but need further development. To stimulate such development an interdisciplinary effort is necessary. Needs of industrial and university users and experience of physicists and instrument manufacturers have to be brought into a hopefully fruitful discussion. An introductory article describes the bioprocess background including a brief summary of the state of the art in bioprocess sensor and parameter estimation development, and the potential MS offers for bioprocess monitoring. In the first chapter on "Instrumentation and Gas Analysis" a general overview on some developments in MS-instrumentation is given initially by Schmid. Then the presently available instrumentation for bioprocess monitoring is discussed by instrument manufacturers (Winter; Schaefer and Schultis; Bartman).


development mass spectrometry spectrometry

Editors and affiliations

  • Elmar Heinzle
    • 1
  • Matthias Reuss
    • 2
  1. 1.Chemical Engineering LaboratoryETHZurichSwitzerland
  2. 2.Technical University of BerlinBerlinFederal Republic of Germany

Bibliographic information