Magnesium Deficiency in the Pathogenesis of Disease

Early Roots of Cardiovascular, Skeletal, and Renal Abnormalities

  • Mildred S. Seelig

Part of the Topics in Bone and Mineral Disorders book series (TBMD)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Introduction: Consideration of Epidemiologic Factors

  3. Magnesium Deficiency during Gestation, Infancy, and Early Childhood

    1. Front Matter
      Pages 27-27
    2. Mildred S. Seelig
      Pages 73-134
  4. Magnesium Deficiency in the Pathogenesis of Cardiovascular Diseases

  5. Skeletal and Renal Effects of Magnesium Deficiency

    1. Front Matter
      Pages 265-265
    2. Mildred S. Seelig
      Pages 267-283
    3. Mildred S. Seelig
      Pages 285-329
    4. Mildred S. Seelig
      Pages 331-346
  6. Back Matter
    Pages 357-488

About this book


There is a large and rapidly growing body of literature on the importance of mag­ nesium in biochemical and physiological processes. There is also much evidence that magnesium deficiency, alone and in combination with agents that interfere with its utilization, is associated with functional and structural abnormalities of mem­ branes, cells, organs, and systems. The manifestations of the changes caused by magnesium deficiency depend upon its extent and duration and on variable factors. Among the conditions that increase the risk of magnesium deficiency are (1) meta­ bolic factors that affect the absorption, distribution, and excretion of this mineral; (2) disease and therapy; (3) physiologic states that increase requirements for nutrients; and (4) nutritional imbalances. Excesses of nutrients that interfere with the absorption or increase the excretion of magnesium-such as fat, phosphate, sugar, and vitamin D-can contribute to long-lasting relative magnesium deficiency. All have been implicated in several of the diseases considered in this book. Whether their influence on the need for magnesium is a common denominator remains to be investigated further.


bone cell circulation electrocardiogram (ECG) fetus heart heart disease infection osteoarthritis osteoporosis pathogenesis pathology surgery thrombosis tissue

Authors and affiliations

  • Mildred S. Seelig
    • 1
  1. 1.Goldwater Memorial HospitalNew York University Medical CenterNew YorkUSA

Bibliographic information