Cholinergic Mechanisms

1. Peripheral Cholinergic Synapses: Heart, Myenteric Plexus and Neuromuscular Function

   1. Early Effects of Denervation on Acetylcholine and Choline Acetyltransferase in Skeletal Muscle

      • R. Miledi, P. C. Molenaar, R. L. Polak

      Pages 205-214

   2. Release of Acetylcholine Triggered by the Venom of Glycera Convoluta

      • R. Manaranche, M. Thieffry, M. Israel

      Pages 215-220

   3. Electrophysiological and Morphological Correlates of the Re-Innervation of Rat Neuromuscular Junction: Implications on the Role of Membrane Components such as Gangliosides in the Motor Nerve Sprouting

      • A. Gorio, G. Carmignoto, M. Finesso, A. Leon, P. Marini, L. Tredese et al.

      Pages 221-233

   4. Isolation of Synaptic Vesicles from the Myenteric Plexus of Guinea Pig

      • G. H. C. Dowe, H. Kilbinger, V. P. Whittaker

      Pages 235-240

2. Peripheral Cholinergic Synapses: Presynaptic Mechanisms

   1. The Structure of Cholinergic Synaptic Vesicles

      • H. Stadler

      Pages 241-247

   2. Inhibition of Membrane Transport Systems in Synaptosomes from Torpedo Electric Organ by Snake Neurotoxins

      • M. J. Dowdall, P. Fretten

      Pages 249-259

   3. Biochemical and Biophysical Aspects of Stimulation Induced Vesicle Heterogeneity in Cholinergic Synaptic Vesicles

      • P. E. Giompres, H. Zimmermann, V. P. Whittaker

      Pages 261-272

   4. Acetylcholine Storage and Calcium Clearance by Synaptic Vesicles

      • M. Israel

      Pages 273-286

   5. Acetylcholine Changes During Transmission of a Single Nerve Impulse

      • Y. Dunant, J. Corthay, L. Eder, F. Loctin

      Pages 287-299

   6. Uptake of Acetylcholine into Torpedo Synaptic Vesicles In Vitro

      • Y. A. Luqmani, P. Giompres

      Pages 301-306

   7. A Vesicular Site of Origin for the Release of a Cholinergic False Transmitter at the Torpedo Synapse

      • Y. A. Luqmani, V. P. Whittaker

      Pages 307-312

   8. Transmembrane Potential and Cation Diffusion Gradients in Isolated Cholinergic Synaptic Vesicles: Possible Model for Energization of Vesicular Acetylcholine Uptake

      • J. B. Suszkiw

      Pages 313-320

   9. Incorporation of Acetate into Acetylcholine and Other Compounds in the Torpedo Electric Organ

      • J. Corthay, F. Loctin, Y. Dunant

      Pages 321-322

3. Peripheral Cholinergic Synapse: Postsynaptic Aspects

   1. Cholinergic Receptor Isolation

      • W. H. Hopff, A. A. Hofmann, G. Riggio, P. G. Waser

      Pages 323-332

   2. New Evidence for True Immunopharmacologic Blockade in Myasthenia Gravis

      • A. K. Lefvert, S. Cuenoud, B. W. Fulpius

      Pages 333-341

   3. Immunohistochemical Demonstration of IgG and Fab Fragments at Motor Endplates of Passively Transferred Mice

      • B. Lowenadler, E. Heilbronn, K. Toyka

      Pages 343-349

   4. On the Effects of Anticholinergic Agents on Muscarinic Receptors of Different Localization

      • D. A. Kharkevich, A. P. Skoldinov, D. N. Samoilov, V. A. Shorr

      Pages 351-365

4. Peripheral Cholinergic Synapse: Axonal Aspects

   1. Ligand Interactions of Axonal Membranes

      • H. C. Mautner, J. E. Jumblatt, J. K. Marquis

      Pages 367-376

   2. Axonal Transport of Choline Phosphoglycerides to Cholinergic Synapses

      • B. Droz, M. Brunetti, L. di Giamberardino, H. L. Koenig, G. Porcellati

      Pages 377-386

   3. Acetylcholinesterase and Butyrylcholinesterase: Similarities in Normal and Denervated Muscles, Differences in Axonal Transport

      • L. di Giamberardino, J. Y. Couraud

      Pages 387-392

Every three years early Spring witnesses the convening of a small group of neuroscientists from many parts of the world. They are devoted to the study of acetylcholine, the oldest of the known neurotransmitters. To assess the level of knowledge, to take stock of the still unsolved problems, to evaluate the practical meaning of their findings, the cholinologists first met in 1969 in the eerie atmosphere of a snow-covered Swedish forest, the second in the Swiss Alps, the third facing the surf and foam of the Paci­ fic waves. Finally in March 1980 Florence, her trees burgeoning in the mild rain of March, confronted them with the temptation of her monuments and museums. But the cholinologists bravely dismis­ sed the temptations and went on with the presentations and discus­ sions of the many papers which form the present book. The papers describe the most recent development of investiga­ tions on acetylcholine. They open with an extensive coverage of the developmental and phylogenetic aspects of the cholinergic neurons. The regulation of acetylcholine synthesis, release, post­ synaptic, electrical and trophic effects in the peripheral chol­ inergic synapses including ganglia, neuromuscular junction, myen­ theric plexus and heart is then covered. Special emphasis is given to the cholinergic mechanisms in the eye.

• Foam
• atmosphere
• brain
• cortex
• development
• forest
• neurotransmitter
• paper
• receptor
• regulation
• synthesis

• Institute of Pharmacology, University of Florence, Florence, Italy

  Giancarlo Pepeu

• Mario Negri Institute for Pharmacological Research, Milan, Italy

  Herbert Ladinsky

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