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Serine Proteases and Their Serpin Inhibitors in the Nervous System

Regulation in Development and in Degenerative and Malignant Disease

  • Barry W. Festoff
  • Daniel Hantaï
Book

Part of the NATO ASI Series book series (NSSA, volume 191)

Table of contents

  1. Front Matter
    Pages i-xxv
    PDF

  2. Biochemistry and cell biology of serine proteases and serpins

    1. Front Matter
      Pages 1-1
      PDF
    2. Thrombin Structural Regions in Determining Bioregulatory Functions
      John W. Fenton II
      Pages 3-7
    3. Regulation and Control of the Fibrinolytic System
      H. Roger Lijnen, Désiré Collen
      Pages 9-20
    4. A Key Molecule Dictating and Regulating Surface Plasmin Formation : The Receptor for Urokinase Plasminogen Activator
      Francesco Blasi, M. Vittoria Cubellis, Ann Louring Roldan, Maria Teresa Masucci, Niels Behrendt, Vincent Ellis et al.
      Pages 21-30
    5. Regulation of Tissue Plasminogen Activator Secretion from Human Endothelial Cells
      Eugene G. Levin, Keith R. Marotti, Lydia Santell
      Pages 31-39
    6. Thrombin Disintegrates Cell Surface Urokinase Focal Adhesion Plaques and Decreases Cell Extension: Implications for Axonal Growth
      Caroline A. Hébert, Joffre B. Baker
      Pages 41-50
    7. Structure and Function of Tissue-Type Plasminogen Activator
      Anton Jan Van Zonneveld, Carlie De Vries, Hans Pannekoek
      Pages 51-68
    8. The Heparin Binding Site and Activation of Protease Nexin I
      Dyfed LL. Evans, Peter B. Christey, Robin W. Carrell
      Pages 69-78
    9. Polypeptide Chain Structure of Inter-α-Trypsin Inhibitor and Pre-α-Trypsin Inhibitor: Evidence for Chain Assembly by Glycan and Comparison with other “Kunin”-Containing Proteins
      Jan J. Enghild, Ida B. Thørgersen, Salvatore V. Pizzo, Guy Salvesen
      Pages 79-91
    10. Regulation of Protease Nexin-1 Activity and Target Protease Specificity by the Extracellular Matrix
      Dennis D. Cunningham, David H. Farrell, Steven L. Wagner
      Pages 93-102

  3. Molecular biology of serine proteases and serpins

    1. Front Matter
      Pages 103-103
      PDF
    2. Induction of the Urokinase-Type Plasminogen Activator Gene by Cytoskeleton-Disrupting Agents
      Florence M. Botteri, Herman van der Putten, Bhanu Rajput, Kurt Ballmer-Hofer, Yoshikuni Nagamine
      Pages 105-114
    3. Use of Protein Chemistry and Molecular Biology to Determine Interaction Areas Between Proteases and their Inhibitors: The Thrombin-Hirudin Interaction as an Example
      Stuart R. Stone, Stanley Dennis, Andrew Wallace, Jan Hofsteenge
      Pages 115-126
    4. Signal Transduction Chains Involved in the Control of the Fibrinolytic Enzyme Cascade
      Wolf-Dieter Schleuning, Robert L. Medcalf
      Pages 127-135
    5. Rodent Serpins : Accelerated Evolution and Novel Specificities
      John D. Inglis, Robert E. Hill
      Pages 137-145
    6. Structure of the Human Protease Nexin Gene and Expression of Recombinant Forms of PN-I
      Michael McGrogan, Jackie Kennedy, Fred Golini, Nina Ashton, Frances Dunn, Kimberly Bell et al.
      Pages 147-161
    7. Evolutionary Adaptations of Serpins and their Use in Designing New Proteinase Inhibitors
      Jan Potempa, Bie-Hue Shieh, Amelia Guzdek, Adam Dubin, Amy Colquhoun, James Travis
      Pages 163-170

  4. Serine proteases in the nervous system

    1. Front Matter
      Pages 171-171
      PDF
    2. Plasminogen Activator in the Developing Nervous System
      Nicholas W. Seeds, Shahla Verrall, Paul McGuire, Glenn Friedman
      Pages 173-184
    3. Multiple Roles for Plasminogen Activator System in Nervous System Development
      Pierre Leprince, Bernard Rogister, Paul Delrée, Philippe P. Lefebvre, Jean-Michel Rigo, Gustave Moonen
      Pages 185-197
    4. Interaction of Plasminogen Activators with the Neuronal Surface
      Randall N. Pittman, Ann Repka, Jeff H. Ware, Ann Marie LaRosa
      Pages 199-208
    5. Glial Plasminogen Activators in Developing and Regenerating Neural Tissue
      Nurit Kalderon
      Pages 209-217
    6. Plasminogen Activators in Development, Injury and Pathology of the Neuromuscular System
      Daniel Hantaï, Claudine Soria, Jeannette Soria, Brigitte Blondet, Georgia Barlovatz-Meimon, Jasti S. Rao et al.
      Pages 219-228
    7. Relationship Between Plasminogen Activators and Regeneration Capacities of Rat Skeletal Muscles
      Georgia Barlovatz-Meimon, Éric Frisdal, Yann Bassaglia, Daniel Hantaï, Eduardo Anglés-Cano, Jean Gautron
      Pages 229-241

  5. Balance of serine proteases and serpins in the nervous system

    1. Front Matter
      Pages 243-243
      PDF
    2. A Cascade Approach to Synapse Formation Based on Thrombogenic and Fibrinolytic Models
      Barry W. Festoff, Jasti S. Rao, Bokka R. Reddy, Daniel Hantaï
      Pages 245-253
    3. Localized Extracellular Proteolysis May Convey Inductive Signals Between Nerve and Muscle Cells During Synaptogenesis
      M. John Anderson, Lauren E. Swenarchuk, Shasikant Champaneria
      Pages 255-273
    4. Steps in Establishing a Biological Relevance for Glia-Derived Nexin
      Denis Monard, Eva Reinhard, Roland Meier, Juerg Sommer, Lynne Farmer, Giorgio Rovelli et al.
      Pages 275-281

  6. Serpins in Degenerative and Malignant Neurologic Diseases

    1. Front Matter
      Pages 283-283
      PDF
    2. Protease Inhibitors in Neurologic Diseases
      Noriaki Adachi
      Pages 285-291
    3. Presence and Significance of α1-Antitrypsin in Human Brain Tumors
      Raymond Sawaya
      Pages 293-299
    4. Serpins and Brain Tumors: Roles in Pathogenesis
      Jasti S. Rao, Riichiro Suzuki, Barry W. Festoff
      Pages 301-311
    5. A Serine Protease Inhibitor Domain Encoded Within the Alzheimer Disease-Associated Amyloid ß-Protein Precursor Gene
      Rudolph E. Tanzi
      Pages 313-319
    6. The Serpin, α1-Antichymotrypsin, in Brain Aging and Diseases of the Nervous System
      Carmela R. Abraham, Huntington Potter
      Pages 321-327
    7. Protease Nexin I Immunostaining in Alzheimer’s Disease
      Dorrie E. Rosenblatt, Changiz Geula, Marsel-Marek Mesulam
      Pages 329-336
  7. Back Matter
    Pages 337-359
    PDF

About this book

Keywords

Amino acid DNA Evolution Nervous System Oxidation Pathogene Polypeptide RNA biochemistry enzymes gene expression proteins transcription

Editors and affiliations

  • Barry W. Festoff
    • 1
  • Daniel Hantaï
    • 2
  1. 1.Veterans Administration Medical CenterUniversity of Kansas Medical CenterKansas CityUSA
  2. 2.I.N.S.E.R.M.ParisFrance

Bibliographic information