Serine Proteases and Their Serpin Inhibitors in the Nervous System

Regulation in Development and in Degenerative and Malignant Disease

  • Barry W. Festoff
  • Daniel Hantaï
Book

Part of the NATO ASI Series book series (NSSA, volume 191)

Table of contents

  1. Front Matter
    Pages i-xxv
    PDF

  2. Biochemistry and cell biology of serine proteases and serpins

    1. Front Matter
      Pages 1-1
      PDF
    2. Thrombin Structural Regions in Determining Bioregulatory Functions
      John W. Fenton II
      Pages 3-7
    3. Regulation and Control of the Fibrinolytic System
      H. Roger Lijnen, Désiré Collen
      Pages 9-20
    4. A Key Molecule Dictating and Regulating Surface Plasmin Formation : The Receptor for Urokinase Plasminogen Activator
      Francesco Blasi, M. Vittoria Cubellis, Ann Louring Roldan, Maria Teresa Masucci, Niels Behrendt, Vincent Ellis et al.
      Pages 21-30
    5. Regulation of Tissue Plasminogen Activator Secretion from Human Endothelial Cells
      Eugene G. Levin, Keith R. Marotti, Lydia Santell
      Pages 31-39
    6. Thrombin Disintegrates Cell Surface Urokinase Focal Adhesion Plaques and Decreases Cell Extension: Implications for Axonal Growth
      Caroline A. Hébert, Joffre B. Baker
      Pages 41-50
    7. Structure and Function of Tissue-Type Plasminogen Activator
      Anton Jan Van Zonneveld, Carlie De Vries, Hans Pannekoek
      Pages 51-68
    8. The Heparin Binding Site and Activation of Protease Nexin I
      Dyfed LL. Evans, Peter B. Christey, Robin W. Carrell
      Pages 69-78
    9. Polypeptide Chain Structure of Inter-α-Trypsin Inhibitor and Pre-α-Trypsin Inhibitor: Evidence for Chain Assembly by Glycan and Comparison with other “Kunin”-Containing Proteins
      Jan J. Enghild, Ida B. Thørgersen, Salvatore V. Pizzo, Guy Salvesen
      Pages 79-91
    10. Regulation of Protease Nexin-1 Activity and Target Protease Specificity by the Extracellular Matrix
      Dennis D. Cunningham, David H. Farrell, Steven L. Wagner
      Pages 93-102

  3. Molecular biology of serine proteases and serpins

    1. Front Matter
      Pages 103-103
      PDF
    2. Induction of the Urokinase-Type Plasminogen Activator Gene by Cytoskeleton-Disrupting Agents
      Florence M. Botteri, Herman van der Putten, Bhanu Rajput, Kurt Ballmer-Hofer, Yoshikuni Nagamine
      Pages 105-114
    3. Use of Protein Chemistry and Molecular Biology to Determine Interaction Areas Between Proteases and their Inhibitors: The Thrombin-Hirudin Interaction as an Example
      Stuart R. Stone, Stanley Dennis, Andrew Wallace, Jan Hofsteenge
      Pages 115-126
    4. Signal Transduction Chains Involved in the Control of the Fibrinolytic Enzyme Cascade
      Wolf-Dieter Schleuning, Robert L. Medcalf
      Pages 127-135
    5. Rodent Serpins : Accelerated Evolution and Novel Specificities
      John D. Inglis, Robert E. Hill
      Pages 137-145
    6. Structure of the Human Protease Nexin Gene and Expression of Recombinant Forms of PN-I
      Michael McGrogan, Jackie Kennedy, Fred Golini, Nina Ashton, Frances Dunn, Kimberly Bell et al.
      Pages 147-161
    7. Evolutionary Adaptations of Serpins and their Use in Designing New Proteinase Inhibitors
      Jan Potempa, Bie-Hue Shieh, Amelia Guzdek, Adam Dubin, Amy Colquhoun, James Travis
      Pages 163-170

  4. Serine proteases in the nervous system

    1. Front Matter
      Pages 171-171
      PDF
    2. Plasminogen Activator in the Developing Nervous System
      Nicholas W. Seeds, Shahla Verrall, Paul McGuire, Glenn Friedman
      Pages 173-184

About this book

Keywords

Amino acid DNA Evolution Nervous System Oxidation Pathogene Polypeptide RNA biochemistry enzymes gene expression proteins transcription

Editors and affiliations

  • Barry W. Festoff
    • 1
  • Daniel Hantaï
    • 2
  1. 1.Veterans Administration Medical CenterUniversity of Kansas Medical CenterKansas CityUSA
  2. 2.I.N.S.E.R.M.ParisFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-8357-4
  • Copyright Information Springer-Verlag US 1990
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-8359-8
  • Online ISBN 978-1-4684-8357-4
  • About this book