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Excitatory Amino Acids and Epilepsy

  • Robert Schwarcz
  • Yehezkel Ben-Ari

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 203)

Table of contents

  1. Front Matter
    Pages i-xi
  2. The Limbic System: Neuroanatomical Concepts Relating to Epileptic Phenomena

  3. Epileptic Brain Tissue: Neuropathology and Physiology in Animals and Man

  4. Excitatory Amino Acids and the Blood-Brain Barrier

    1. Front Matter
      Pages 173-173
    2. J. M. Lefauconnier, Y. Tayarani, G. Bernard
      Pages 191-198
    3. M. L. Berger, J.-M. Lefauconnier, E. Tremblay, Y. Ben-Ari
      Pages 199-209
    4. H. Lassmann, H. Baran, U. Petsche, K. Kitz, G. Sperk, O. Hornykiewicz et al.
      Pages 223-230
  5. Excitatory Amino Acids: Receptor Interactions

    1. Front Matter
      Pages 235-235
    2. M. Cuénod, K. Q. Do, P. L. Herrling, W. A. Turski, C. Matute, P. Streit
      Pages 253-262
    3. O. P. Ottersen, J. Storm-Mathisen
      Pages 263-284
    4. F. Fonnum, R. H. Paulsen, V. M. Fosse, B. Engelsen
      Pages 285-293
    5. V. I. Teichberg, M. Beaujean, P. David, D. Eisenberg-Tamarin, U. Erez, H. Frenk et al.
      Pages 295-301
  6. Excitatory Amino Acids and Seizures: Neurochemical Interrelationships

    1. Front Matter
      Pages 319-319
    2. E. D. French, A. Vezzani, W. O. Whetsell Jr., R. Schwarcz
      Pages 349-362
    3. A. Lehmann, H. Hagberg, J. W. Lazarewicz, I. Jacobson, A. Hamberger
      Pages 363-373
    4. J. T. Coyle, R. Blakely, R. Zaczek, K. J. Koller, M. Abreu, L. Ory-Layollée et al.
      Pages 375-384
  7. Mechanisms of Epileptogenesis

    1. Front Matter
      Pages 389-389
    2. W. E. Crill, P. C. Schwindt, J. A. Flatman, C. E. Stafstrom, W. Spain
      Pages 401-411
    3. J. F. MacDonald, J. H. Schneiderman, Z. Miljkovic
      Pages 425-437
  8. Excitatory Amino Acids: Physiological Studies

  9. Metal Ions and Epilepsy

    1. Front Matter
      Pages 543-543

About this book

Introduction

Human epilepsy is a major public health problem affecting approximately 2 persons per 1000. It is particularly frequent in ohildren where convul­ sions may lead to brain damage and subsequent seizure activity in adulthood. Temporal lobe epilepsy (synonyms include limbic epilepsy. psychomotor epilepsy and complex partial epilepsy) is the most devastating form of epilepsy in the adult population since: a) it is often extremely resistant to currently available anticonvulsant drugs (i.e •• it is more resistant than tonico-clonic or grand mal seizures) and b) it includes loss of consciousness. thereby limiting performance of many normal functions and leaving the individual susceptible to bodily injury. It is also associated with nerve cell loss. in particular in the hippocampus and other structures of the temporal lobes. In order to promote an appropriate therapy it is essential to understand the etiology of seizures and its relationship to brain damage. Basic research on epilepsy also provides a very useful vehicle to learn about the way the brain functions under normal conditions. For instance. much of our present understanding of the mechanisms of action of GABA and benzo­ diazepines. control of neuronal activity. etc. has been derived from such stUdies.

Keywords

Aspartat Glutamat amino acid brain cell etiology lead population protein receptor structure synthesis therapy

Editors and affiliations

  • Robert Schwarcz
    • 1
  • Yehezkel Ben-Ari
    • 2
  1. 1.Maryland Psychiatric Research CenterUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.INSERM-U29Hôpital de Port-RoyalParisFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-7971-3
  • Copyright Information Springer-Verlag US 1986
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-7973-7
  • Online ISBN 978-1-4684-7971-3
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site