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Neonatal Jaundice

New Trends in Phototherapy

  • Firmino F. Rubaltelli
  • Giulio Jori

Table of contents

  1. Front Matter
    Pages i-xi
  2. Bilirubin Metabolism

    1. Maurizio Muraca, Norbert Blanckaert, Johan Fevery, Firmino F. Rubaltelli, Virgilio Carnielli, Gianna Pettenà
      Pages 13-21
    2. P. Meisel, D. Jährig, I. Weinke, K. Jährig
      Pages 45-49
  3. Assessment of the Risk of Bilirubin Toxicity

    1. Rolf Brodersen, Christian Jacobsen, Henning Iversen, Frank Lundquist
      Pages 51-54
    2. William J. Cashore, Masahisa Funato
      Pages 69-77
  4. Chenistry and Photochemistry of Bilirubin

  5. Phototherapy of Neonatal Jaundice

    1. John F. Ennever, William T. Speck
      Pages 187-196
    2. G. P. Donzelli, M. G. Migliorini, R. Pratesi, G. Sbrana, C. Vecchi
      Pages 197-214
    3. Leonore Ballowitz, Folker Hanefeld, Günther Wiese
      Pages 225-233
    4. D. Nicolopoulos, E. Hadjigeorgiou, A. Malamitsi-Puchner, N. Kalpoyannis
      Pages 257-263
    5. F. F. Rubaltelli, G. Jori, E. Rossi, G. Garbo
      Pages 265-275
    6. T. R. C. Sisson, S. C. Glauser, E. M. Glauser, G. Chan, N. Romayananda
      Pages 277-290
    7. B. R. Sonawane, B. Granati, L. Chiandetti, F. F. Rubaltelli, T. R. C. Sisson, S. J. Yaffe
      Pages 291-301
  6. Back Matter
    Pages 315-321

About this book

Introduction

Hyperbilirubinemia of the neonate and the related risk of brain damage with conseguent important alterations in motor development, particularly in sick preterm babies, remains a major problem in nurseries throughout the world. Since its introduction in the 1950's phototherapy has been used for reducing serum bilirubin concentrations in the newborn with hyperbilirubinemia; however, only recently the photoprocesses invoked by light on various substrates including bilirubin have been clari­ fied in sufficient detail. Light treatment actually exemplifies the intimate relationship between the clinical and basic sciences: the better understanding of the mechanism of phototherapy as a result of investigations initiated in the laboratory has been extended to the bedside as new types of lamps or new schedules of treatment. As a consequence, phototherapy of hyperbilirubinemia has emerged as a well-established branch of photomedicine, based on molecular photo­ biology, scientific method, and creative use of physics and sophis­ ticated electrooptical capabilities. The collaboration and exchange of information between workers in different basic and clinical di­ sciplines is likely to stimulate a further optimization of photo­ therapy. The purpose of this monograph is to discuss some of the new aspects of bilirubin metabolism and phototherapeutic treatment. Bilirubin conjugation in the fetal and early neonatal life, the mechanism of bilirubin entry into the brain, the measurements of bilirubin concentration in the skin and serum bilirubin binding capacity are discussed by a number of prominent neonatologists.

Keywords

Laboratory biology brain development medicine metabolism newborn physics skin therapy treatment

Editors and affiliations

  • Firmino F. Rubaltelli
    • 1
  • Giulio Jori
    • 2
  1. 1.Department of PediatricsUniversity of PaduaPaduaItaly
  2. 2.Department of BiologyUniversity of PaduaPaduaItaly

Bibliographic information