Advertisement

Table of contents

  1. Front Matter
    Pages i-xii
  2. Paul E. Kroeger, Richard I. Morimoto
    Pages 25-61
  3. Ulrich Siebenlist, Keith Brown, Guido Franzoso
    Pages 93-141
  4. Béatrice Desvergne, Walter Wahli
    Pages 142-176
  5. Rainer Heuchel, Freddy Radtke, Walter Schaffner
    Pages 206-240
  6. Back Matter
    Pages 267-284

About this book

Introduction

Cells have evolved multiple strategies to adapt the composition and quality of their protein equipment to needs imposed by changes in intra- and extracellular conditions. The appearance of pro teins transmit­ ting novel functional properties to cells can be controlled at a transcrip­ tional, posttranscriptional, translational or posttranslational level. Extensive research over the past 15 years has shown that transcriptional regulation is used as the predominant strategy to control the production of new proteins in response to extracellular stimuli. At the level of gene transcription, the initiation ofmRNA synthesis is used most frequently to govern gene expression. The key elements controlling transcription initiation in eukaryotes are activator proteins (transactivators) that bind in a sequence-specific manner to short DNA sequences in the of genes. The activator binding sites are elements of larger proximity control units, ca lied promoters and enhancers, which bind many distinct proteins. These may synergize or negatively cooperate with the activators. The do novo binding of an activator to DNA or, if already bound to DNA, its functional activation is what ultimately turns on a high-level expression of genes. The activity of transactivators is controlled by signalling pathways and, in some cases, transactivators actively partici­ pate in signal transduction by moving from the cytoplasm into the nuc1eus. In this first volume of Inducible Gene Expression, leading scientists in the field review six eukaryotic transactivators that allow cells to respond to various extracellular stimuli by the expression of new proteins.

Keywords

DNA gene expression genes Promoter stress transcription translation

Editors and affiliations

  • P. A. Baeuerle
    • 1
  1. 1.Institute of BiochemistryAlbert-Ludwigs-University FreiburgFreiburg i.Br.Germany

Bibliographic information