Presynaptic Receptors in the Mammalian Brain

  • Thomas V. Dunwiddie
  • David M. Lovinger

Table of contents

  1. Front Matter
    Pages i-x
  2. Kenneth P. Scholz
    Pages 1-13
  3. Stephen H. Williams, Daniel Johnston
    Pages 27-41
  4. Steven W. Johnson, R. Alan North
    Pages 71-86
  5. William F. Colmers, A. Rory McQuiston, Samuel B. Kombian, Gloria J. Klapstein
    Pages 87-103
  6. David M. Lovinger, Nevin A. Lambert
    Pages 127-142
  7. Nevin A. Lambert, Neil L. Harrison
    Pages 143-160
  8. Darrell V. Lewis, David D. Mott, H. Scott Swartzwelder, Cui-Wei Xie
    Pages 161-179
  9. Back Matter
    Pages 197-199

About this book


Trying to address the entire field of presynaptic modulation of neurotransmitter release is a rather daunting undertaking, one that is well beyond the scope of this book. In addition, studies of release modulation, particularly from a biochemical standpoint, have been the subjects of several extensive reviews, meetings, and books (Langer, 1978; Chesselet, 1984; Wessler, 1989; Kalsner and Westfall, 1990), which provide an essential introduction to this subject. What we have focused on, however, are several specific aspects of release modulation that perhaps have not been as extensively discussed. First, we felt that it was important to focus on modulation in the central nervous system; much of the work that has been done in the past has emphasized the peripheral nervous system (e. g. , the autonomic nervous system and the neuromuscular junction), in part because such preparations are more amenable to study. However, it is becoming clear that modulation of release is, if anything, more important in the central nervous system than in the periphery, and that virtually every transmitter system that has been studied shows some type of release modulation. The other way in which we have restricted the scope of this volume has been to try to emphasize studies in which functional (primarily electrophysiological) measures of transmitter release have been used rather than direct biochemical measures of release, and to explore the ways in which release modulation affects the normal physiological function at synapses.


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Editors and affiliations

  • Thomas V. Dunwiddie
    • 1
    • 2
  • David M. Lovinger
    • 3
  1. 1.V.A. Medical CenterDenverUSA
  2. 2.Department of Pharmacology C-236University of Colorado Health Sciences CenterDenverUSA
  3. 3.Department of Molecular Physiology and BiophysicsVanderbilt University School of MedicineNashvilleUSA

Bibliographic information