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Cytotoxic Cells: Recognition, Effector Function, Generation, and Methods

  • Michail V. Sitkovsky
  • Pierre A. Henkart

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Introduction and Overview

    1. Front Matter
      Pages 1-1
    2. Herman N. Eisen
      Pages 3-4
    3. Jean-Charles Cerottini
      Pages 5-8
  3. Target Cell Recognition

    1. Front Matter
      Pages 47-47
    2. David H. Margulies, Lisa F. Boyd, Maripat Corr, Rosemarie D. Hunziker, Sergei Khilko, Steven Kozlowski et al.
      Pages 58-64
    3. Anne M. O’Rourke, Matthew F. Mescher
      Pages 65-71
    4. Shigeo Koyasu, Ellis L. Reinherz
      Pages 72-83
    5. Lewis L. Lanier, Joseph H. Phillips
      Pages 84-95
    6. David M. Segal, Carolina R. Jost, Andrew J. T. George
      Pages 96-110
  4. Generation of Cytotoxic Cells

    1. Front Matter
      Pages 111-111
    2. Mark R. Alderson, Michael B. Widmer
      Pages 128-137
    3. Maurice K. Gately, Aimee G. Wolitzky, Phyllis M. Quinn, Richard Chizzonite
      Pages 138-144
    4. J. A. Frelinger, D. G. Quinn, D. Muller
      Pages 145-150
  5. Molecular Mechanisms of Cellular Cytotoxicity

  6. Granule Proteases

    1. Front Matter
      Pages 235-235
    2. Patrick Haddad, Dieter E. Jenne, Olivier Krähenbühl, Jürg Tschopp
      Pages 251-262
    3. Gillian M. Griffiths, Susan Alpert, R. Jane Hershberger, Lishan Su, Irving L. Weissman
      Pages 273-277
    4. Dorothy Hudig, N. Janine Allison, Gerald R. Ewoldt, Ruth Gault, Dale Netski, Timothy M. Pickett et al.
      Pages 295-304
  7. Alternative Mechanisms of Cytolysis

    1. Front Matter
      Pages 305-305
    2. Frank Redegeld, Antonio Filippini, Guido Trenn, Michail V. Sitkovsky
      Pages 307-313
    3. Francesco Di Virgilio, Paola Zanovello, Dino Collavo
      Pages 314-320
  8. Biochemical and Immunopharmacological Manipulations of Cytotoxic Cells

  9. Functions of Cytotoxic Cells In Vivo

    1. Front Matter
      Pages 349-349
    2. Peter C. Doherty, William Allan, Maryna Eichelberger, Sam Hou, Jacqueline M. Katz, Rudolf Jaenisch et al.
      Pages 351-357
    3. Raymond M. Welsh, Paul R. Rogers, Randy R. Brutkiewicz
      Pages 400-406
    4. Stephen E. Ettinghausen, Steven A. Rosenberg
      Pages 407-435

About this book

Introduction

Our motivation for putting together this book was the need for a single source reference that could be used as an introduction to cell-mediated cytotoxicity for newcomers to this field, such as students and fellows beginning work in our laboratories. At present no such book is available, and we felt that it would be useful as a teaching tool and as a way of conveying our enthusiasm about recent progress in the cytotoxicity field to our colleagues in allied areas. It was with some hesitation that we approached our colleagues with the proposal for this book, and we were pleased to find them very supportive of the idea and willing to participate. We thought it important to broaden the scope of the book to include historical, molecular, cell biological, and clinical aspects of cell-mediated cytotoxicity. To our knowledge this is the first book on cell-mediated cytotoxicity with such a broad scope. Historically, studies on cellular cytotoxicity were part of cellular immunology from its origin. One development of tremendous import was the advent of the 51 Cr assay, which allowed this arm of the immune response to be measured easily and quantitatively. Thus, a readout of this effector pathway is available within a few hours; other immune effector functions can take days or even longer to assay, and the assays are often less quantitative.

Keywords

DNA antibody antigen apoptosis cell clinical trial cytokine cytotoxicity immune response immunology infection molecular biology parasite pharmacology virus

Editors and affiliations

  • Michail V. Sitkovsky
    • 1
  • Pierre A. Henkart
    • 2
  1. 1.Laboratory of Immunology, Biochemistry and Immunopharmacology UnitNIH-NIAIDBethesdaUSA
  2. 2.Experimental Immunology Branch, National Cancer InstituteNational Institutes of HealthBethesdaUSA

Bibliographic information