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Gene Expression

General and Cell-Type-Specific

  • Michael Karin

Part of the Progress in Gene Expression book series (PRGE)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Stefan G. E. Roberts, Michael R. Green
    Pages 1-24
  3. Helen M. Blau
    Pages 25-42
  4. Miguel Beato
    Pages 43-75
  5. John J. Schwarz, James F. Martin, Eric N. Olson
    Pages 93-115
  6. Gennaro Ciliberto, Vittorio Colantuoni, Raffaele De Francesco, Vincenzo De Simone, Paolo Monaci, Alfredo Nicosia et al.
    Pages 162-242
  7. Back Matter
    Pages 297-303

About this book

Introduction

This book is the first volume in a new series Progress in Gene Expres­ sion. The control of gene expression is a central-most topic in molecular biology as it deals with the utilization and regulation of gene informa­ tion. As we see huge efforts mounting all over the developed world to understand the structure and organization of several complex eukaryotic genomes in the form of Gene Projects and Genome Centers, we have to remember that without understanding the basic mechanisms that gov­ ern the use of genetic information, much of this effort will not be very productive. Fortunately, however, research during the past seven years on the mechanisms that control gene expression in eukaryotes has been extremely successful in generating a wealth of information on the basic strategies of transcriptional control. (Although regulation of gene ex­ pression is exerted at many different levels, much of the emphasis in this series will be on transcriptional control. A future volume, however, will deal with other levels of regulation). The progress in understanding the control of eukaryotic transcription can only be appreciated by realizing that seven years ago we did not know the primary structure of a single sequence specific transcriptional activator, and those whose primary structures were available (e. g. , homeo­ domain proteins) were not yet recognized to function in this capacity.

Keywords

gene expression genes molecular biology transcription

Editors and affiliations

  • Michael Karin
    • 1
  1. 1.Department of Pharmacology, School of MedicineUniversity of CaliforniaSan Diego, La JollaUSA

Bibliographic information