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Generalized Epilepsy

Neurobiological Approaches

  • Massimo Avoli
  • Pierre Gloor
  • George Kostopoulos
  • Robert Naquet

Table of contents

  1. Front Matter
    Pages i-xv
  2. Historical Introduction

    1. H. H. Jasper
      Pages 1-15
  3. Clinical Background

    1. Front Matter
      Pages 17-17
    2. F. E. Dreifuss
      Pages 19-29
    3. P. Kellaway, J. D. Frost Jr., J. W. Crawley
      Pages 36-48
  4. Fundamental Cellular and Neurotransmitter Mechanisms

    1. Front Matter
      Pages 49-49
    2. W. E. Crill, P. C. Schwindt, W. J. Spain
      Pages 51-60
    3. C. L. Faingold, B. S. Meldrum
      Pages 102-117
    4. J. Champagnat, C. Silva-Barrat, S. Brailowsky, Ch. Menini
      Pages 118-125
    5. S. Brailowsky, C. Silva-Barrat, Ch. Ménini, D. Riche, R. Naquet
      Pages 126-136
    6. G. Kostopoulos, C. Psarropoulou
      Pages 137-157
  5. Thalamic and Cortical Mechanisms in Absence Attacks

  6. Photosensitivity

    1. Front Matter
      Pages 271-271
    2. A. J. Wilkins, C. D. Binnie, C. E. Darby, D. Kasteleijn-Nolst Trenité
      Pages 314-326
  7. Generalized Convulsive Seizures

  8. Metabolic and Neurochemical Studies

    1. Front Matter
      Pages 385-385
    2. J. Engel Jr., R. F. Ochs, P. Gloor
      Pages 387-396
    3. M. Mazière, E. Brouillet, M. Kunimoto, M. Khalili-Varasteh, Ph. Hantraye, R. H. Dodd et al.
      Pages 397-406
  9. Pharmacological Agents and Generalized Seizures

    1. Front Matter
      Pages 423-423
    2. P. L. Carlen, M. F. Davies, I. Rougier-Naquet, J. N. Reynolds, I. Spigelman
      Pages 460-470
  10. Back Matter
    Pages 471-481

About this book

Introduction

In recent years there has been intense interest in the basic mechanisms of epilepsy. Many symposia and monographs have been devoted to this topic. These reviews, however, have focused almost exclusively on studies performed in models of partial (or focal) epilepsy. It was natural that scientists interested in the fundamental mechanism of epileptogenesis at the cellular level were attracted to work on models in which the epileptogenic dysfunction could be confined to ever-smaller populations of neurons. Many of the most illuminating studies done in this field in the recent past have been carried out in vitro on brain slices or on dissociated neuronal cultures. Much valuable insight into the mechanisms of epileptogenesis has been obtained in this manner. One cannot, however, automatically assume that mechanisms elucidated in such exquisitely "focal" models are applicable to forms of epilepsy in which seizures from their very start involve the entire brain. One of the most difficult questions that arises in this context is how epileptogenic dysfunction, which can be understood in terms of mechanisms involving a few contiguous cells, can lead to what appears to be a simultaneous onset of seizure discharge in virtually all areas of the brain. Most of the workers who have made excellent contributions to the understanding of the cellular mechanisms involved in epileptogenesis have paid virtually no attention to this important problem.

Keywords

PET brain cortex electroencephalography (EEG) epilepsy neurons physiology positron emission tomography (PET) receptor

Editors and affiliations

  • Massimo Avoli
    • 1
  • Pierre Gloor
    • 1
  • George Kostopoulos
    • 2
  • Robert Naquet
    • 3
  1. 1.Montreal Neurological Institute, Department of NeurophysiologyMcGill UniversityMontrealCanada
  2. 2.Department of PhysiologyUniversity of Patras Medical SchoolPatrasGreece
  3. 3.Laboratoire de Physiologie NerveuseCNRSGif-sur-YvetteFrance

Bibliographic information