Animal Models of Depression

  • George F. Koob
  • Cindy L. Ehlers
  • David J. Kupfer

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Animal Models

  3. Developmental Models

    1. Front Matter
      Pages 55-55
    2. Cindy L. Ehlers, Tamara L. Wall, Stephan P. Wyss, R. Ian Chaplin
      Pages 99-110
    3. Martin H. Teicher, Natacha I. Barber, Janet M. Lawrence, Ross J. Baldessarini
      Pages 135-161
    4. George F. Koob
      Pages 162-183
  4. Pharmacologic Models

    1. Front Matter
      Pages 185-185
    2. James L. Howard, Robert M. Ferris, Barrett R. Cooper, Francis E. Soroko, Ching M. Wang, Gerald T. Pollard
      Pages 187-203
    3. R. Francis Schlemmer Jr., Jennifer E. Young, John M. Davis
      Pages 239-260
    4. John D. Fernstrom, Ross H. Pastel
      Pages 261-280
    5. Floyd E. Bloom
      Pages 281-284
  5. Back Matter
    Pages 285-295

About this book


Animal models represent experimental investigations developed in one species for the purpose of studying phenomena in another species and provide numerous advantages for preclinical research. They allow scientists greater control and isolation of important experimental variables. Animal models are safe, reproducible strategies by which to evaluate and design new pharma­ cological treatment strategies, while also allowing direct central nervous system intervention to alter the course of the aberrant behavior. Animal models have been developed for a number of mental illnesses; in this particular domain, they hold the promise to shed light on the still obscure etiologies of these illnesses and ultimately to facilitate the development and testing of "cures. " Yet, true models of mental illness are difficult to develop, because mental illness may be a uniquely human phenomenon. It was based on these considerations that the MacArthur Foundation Research Network on the Psychobiology of Depression set out to sponsor a conference to review the status, problems, promises, and relevance of animal models to the clinical conditions of affective disorders. The conference was held in September 1986 and included participants from both within the Network as well as scientists and scholars from various disciplines relevant to the concerns of the conference. After the conference was held, it became clear to the organizers that the material presented could be helpful to a broader field of investigators, since a significant portion of the information has not been presented elsewhere or in the unified context of a monograph.


behavior biology central nervous system experimental investigations nervous system pharmacology physiology psychiatry stress

Editors and affiliations

  • George F. Koob
    • 1
  • Cindy L. Ehlers
    • 1
  • David J. Kupfer
    • 2
  1. 1.Department of NeuropharmacologyResearch Institute of the Scripps ClinicLa JollaUSA
  2. 2.Department of PsychiatryUniversity of Pittsburgh Medical SchoolPittsburghUSA

Bibliographic information