Cell-Cell Interactions in the Release of Inflammatory Mediators

1. The Role of Leukotriene A4 Hydrolase in Cells and Tissues Lacking 5-Lipoxygenase

   • Hans-Erik Claesson, Jesper Z. Haeggström, Björn Odlander, Juan F. Medina, Anders Wetterholm, Per-Johan Jakobsson et al.

   Pages 307-315

2. Keratinocytes Can Regulate Prostaglandin Synthesis by Fibroblasts: Potential Role for Interleukin 1

   • Marc E. Goldyne, Kerry L. Blacker, Mary L. Williams

   Pages 317-327

3. Neutrophil-Epithelial Cell Interactions in the Intestine

   • James L. Madara, Shirin Nash, Charles Parkos

   Pages 329-334

4. Cell-Cell Interactions in the Regulation of Glomerular Inflammation by Arachidonate Lipoxygenase Products

   • Kamal F. Badr

   Pages 335-346

5. Neutrophil Adhesion to Glomerular Mesangial Cells: Regulation by Lipoxygenase-Derived Eicosanoids

   • Hugh R. Brady, Mark D. Denton, Barry M. Brenner, Charles N. Serhan

   Pages 347-359

6. Enzymatic Formation and Regulatory Function of Lipoxins and Leukotriene B4 in Rat Kidney Mesangial Cells

   • Renee Garrick, Patrick Y.-K. Wong

   Pages 361-369

7. Back Matter

   Pages 371-384

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This volume constitutes. in part. the proceedings of the symposium on "Cell-Cell Interaction and Release of Inflammatory Mediators" organized by Drs. Patrick Y-K Wong and Charles N. Serhan and presented at the FASEB meeting in Washington. D.C. in April. 1990. It contains chapters by the symposium speakers as well as contributions from investigators in this field. Readers will find exciting advances in this volume. which contains chapters dedicated to state-of-the-art knowledge in the field of Cell-Cell Interaction and the functions of released mediators in inflammatory diseases. This book includes "cutting edge" investigations on transcellular eicosanoid biosynthesis. cytokines. PAF, and adhesion as well as interactions of inflammatory cells with endothe 1 i um. 1 ung • and kidney. A 1 so. the contro 1 and regu 1 at ion of renal function by lipid mediators generated during cell-cell i nteracti ons between rena 1 mesangi a 1 cells and 1 eukocytes has generated insight into the cell biology and regulatory role of these mediators in the kidney. Moreover. the relationship between these areas is discussed in sequelae of both asthmatic and renal diseases. We hope that some of the enthusiasm and excitement present in this research are also evident here and that this volume will serve as a reference for researchers. teachers. and students to survey thi s rapidly growing field.

• Colon
• Interleukin 1
• Lipid
• Macrophages
• Regulation
• leukocytes
• metabolism
• neutrophils
• physiology
• polymorphonuclear leukocytes

• New York Medical College, Valhalla, USA

  Patrick Y.-K. Wong

• Harvard Medical School, Boston, USA

  Charles N. Serhan

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