Chemotactic Cytokines

Biology of the Inflammatory Peptide Supergene Family

  • J. Westwick
  • I. J. D. Lindley
  • S. L. Kunkel

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 305)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Marco Baggiolini, Beatrice Dewald, Alfred Walz
    Pages 11-21
  3. Robert M. Strieter, Theodore Standiford, Stephen W. Chensue, Keita Kasahara, Steven L. Kunkel
    Pages 23-30
  4. Naofumi Mukaida, Atsushi Hishinuma, Claus O. C. Zachariae, Joost J. Oppenheim, Kouji Matsushima
    Pages 31-38
  5. Alfred Walz, Roland Zwahlen, Marco Baggiolini
    Pages 39-46
  6. Teizo Yoshimura, Edward J. Leonard
    Pages 47-56
  7. Edward J. Leonard, Alison Skeel, Teizo Yoshimura
    Pages 57-64
  8. Steven L. Kunkel, Theodore Standiford, Keita Kasahara, Robert M. Strieter
    Pages 65-71
  9. Ruth Sager, Stephen Haskill, Anthony Anisowicz, Douglas Trask, Marilyn C. Pike
    Pages 73-77
  10. Rodney S. Kawahara, Zheng-Wen Deng, Thomas F. Deuel
    Pages 79-87
  11. John G. Morgan, H. Anne Pereira, Teresa Sukiennicki, John K. Spitznagel, James W. Larrick
    Pages 89-96
  12. Richard Camp, Kevin Bacon, Nicholas Fincham, Kay Mistry, Janet Ross, Frances Lawlor et al.
    Pages 109-118
  13. Diana Smith, Lisa Burrows, John Westwick
    Pages 119-126
  14. Zarin Brown, Lynette Fairbanks, Robert M. Strieter, Guy H. Neild, Steven L. Kunkel, John Westwick
    Pages 137-145
  15. Ivan J. D. Lindley, Miroslav Ceska, Peter Peichl
    Pages 147-156
  16. J. G. Morgan, H. A. Pereira, T. Sukiennicki, J. K. Spitznagel, J. W. Larrick, D. R. Forsdyke et al.
    Pages 157-179
  17. Back Matter
    Pages 181-186

About this book


The existence of a new family of chemotactic cytokines was realised in 1987 following the isolation and structural determination by several groups of a peptide consisting of 72 amino acids which was a potent activator of neutrophils and a chemotactic agent for lymphocytes. The first symposium of this series was held at the Royal College of Surgeons of England in December 1988, entitled Novel Neutrophil Stimulating Peptides, and brought together the majority of the laboratories which had published in this area, see Immunology Today 10: 146-147(1989). Since the first symposium there has been a dramatic increase in our knowledge of the biology of this family of structurally related peptides. The Second International Symposium on Chemotactic Cytokines was held at the Royal College of Surgeons of England in June 1990. The aim of this symposium was to provide both a forum for discussion and to determine whether this knowledge can be utilised in the design of novel therapeutic strategies for the treatment of inflammatory disorders. Although the majority of studies have been concerned with the regulation of these peptides at the molecular and cellular level, there is now evidence to suggest that specific members of this superfamily have a role in the pathogenesis of a number of diverse diseases including arthritis, psoriasis, atherosclerosis, wound repair, inflammatory lung diseases and glomerulonephritis.


Amino acid Calcium gene expression interferon pathophysiology physiology

Editors and affiliations

  • J. Westwick
    • 1
  • I. J. D. Lindley
    • 2
  • S. L. Kunkel
    • 3
  1. 1.The University of BathAvonUK
  2. 2.Sandoz Research InstituteViennaAustria
  3. 3.University of MichiganAnn ArborUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1991
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-6011-7
  • Online ISBN 978-1-4684-6009-4
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site