Mechanisms of Lymphocyte Activation and Immune Regulation III

Developmental Biology of Lymphocytes

  • Sudhir Gupta
  • William E. Paul
  • Max D. Cooper
  • Ellen V. Rothenberg

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 292)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Phylogeny of Lymphocytes

    1. L. Du Pasquier, J. Schwager
      Pages 1-9
    2. G. W. Litman, C. T. Amemiya, F. A. Harding, R. N. Haire, K. R. Hinds, R. T. Litman et al.
      Pages 11-17
  3. Developmental Biology of T Lymphocytes

    1. Pawel Kisielow, Harald von Boehmer
      Pages 31-42
    2. Dennis Y. Loh
      Pages 43-45
    3. Susumu Tonegawa, Anton Berns, Marc Bonneville, Andrew G. Farr, Isao Ishida, Kouich Ito et al.
      Pages 53-61
    4. James P. Allison, David M. Asarnow, Mark Bonyhadi, Amy Carbone, Wendy L. Havran, Diphankar Nandi et al.
      Pages 63-69
    5. Ellen V. Rothenberg, Dan Chen, Rochelle A. Diamond, Mariam Dohadwala, Thomas J. Novak, Patricia M. White et al.
      Pages 71-83
    6. Christopher E. Rudd, Elizabeth K. Barber, Kristine E. Burgess, Julie Y. Hahn, Andreani D. Odysseos, Man Sun Sy et al.
      Pages 85-96
    7. Takashi Suda, Ian MacNeil, Melissa Fischer, Kevin W. Moore, Albert Zlotnik
      Pages 115-120
    8. Richard J. Armitage, Steven F. Ziegler, M. Patricia Beckmann, Rejean L. Idzerda, Linda S. Park, William C. Fanslow
      Pages 121-130
    9. Frederick A. Fletcher, Kateri A. Moore, Douglas E. Williams, Dirk Anderson, Charles Maliszewski, John W. Belmont
      Pages 131-138
  4. Mechanism of Tolerance Inductions

    1. Fred Ramsdell, Tracy Lantz, Frances Hausman, B. J. Fowlkes
      Pages 139-147
    2. Susan R. Webb, Jonathan Sprent
      Pages 149-157
    3. Marcia A. Blackman, John W. Kappler, Philippa Marrack
      Pages 159-165
    4. Marc K. Jenkins, Daniel Mueller, Ronald H. Schwartz, Simon Carding, Kim Bottomley, Miguel J. Stadecker et al.
      Pages 167-176

About this book

Introduction

Recent advances in the understanding of the major events that shape the immune recog­ nition system have been remarkable. The analysis of immunoglobulin (Ig) gene organization and Ig repertoire diversification in lower vertebrates has provided new insight into this process in mammals. Similarly, the understanding of the early development of lymphocytes and of the acquisition of immunological tolerance has been aided by elegant studies in quail/chicken chimeras, using the power of the distinctive markers of the constitutive cells of these birds. Great strides have been made in understanding the role played by major histocompatibility complex (MHC) molecules in antigen presentation and in repertoire selec­ tion within the thymus. The use of transgenic mice expressing specific T-cell receptor (TCR) genes has elucidated the process of both positive and negative selection. In parallel, there has been considerable progress in our understanding of tolerance, based in part on the use of markers for the V fJ genes of T-cell receptors and in part on the analysis of the behavior of long term T-cell lines. This has led to the realization that both clonal deletion and clonal anergy may play critical roles in the maintenance of unresponsiveness to self antigen. Molecular analysis of the requirements for expression of membrane immunoglobulin molecules has revealed the existence of a complex that appears to be of critical importance in mediating signalling through Ig receptors. In addition, major insights have been obtained into the regulation of expression of genes of immunologic interest.

Keywords

Antigen antigen presentation cells development histocompatibility immunoglobulin lymphocytes system vertebrates

Editors and affiliations

  • Sudhir Gupta
    • 1
  • William E. Paul
    • 2
  • Max D. Cooper
    • 3
  • Ellen V. Rothenberg
    • 4
  1. 1.Department of MedicineUniversity of CaliforniaIrvineUSA
  2. 2.Laboratory of Immunology, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA
  3. 3.The Howard Hughes Medical InstituteUniversity of AlabamaBirminghamUSA
  4. 4.Department of BiologyCalifornia Institute of TechnologyPasadenaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-5943-2
  • Copyright Information Springer-Verlag US 1991
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-5945-6
  • Online ISBN 978-1-4684-5943-2
  • Series Print ISSN 0065-2598
  • About this book