Genetics and Product Formation in Streptomyces

  • Simon Baumberg
  • Hans Krügel
  • Dieter Noack

Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 55)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Transcription/Translation, Primary/Secondary Metabolism, Differentiation

    1. K. F. Chater
      Pages 1-2
    2. Keith F. Chater, Celia J. Bruton, Nigel K. Davis, Kitty A. Plaskitt, Juan Soliveri, Huarong Tan
      Pages 3-9
    3. F. Szeszák, S. Vitális, I. Békési, G. Szabó
      Pages 11-18
    4. G. Padilla, Z. Hindle, R. Callis, A. Corner, M. Ludovice, P. Liras et al.
      Pages 35-45
    5. J. Stefan Rokem, Astrid Schön, Dieter Söll
      Pages 47-52
    6. J. Weiser, J.-L. Pernodet, M. Cassan, M. Ehrenberg, J. Náprstek, M. Guerineau et al.
      Pages 53-63
  3. Antibiotic Synthesis

    1. Iain S. Hunter
      Pages 83-85
    2. A. L. Demain, J. M. Piret
      Pages 87-103
    3. Kenneth J. McDowall, Deirdre Doyle, Michael J. Butler, Craig Binnie, Melvyn Warren, Iain S. Hunter
      Pages 105-116
    4. Natalie Lomovskaya, Gennady Sezonov, Lyubov Isayeva, Tatyana Chinenova
      Pages 117-127
    5. Helmut Häcker, Otto Pfeifer, Frauke Thiermann, Maria Weng, Franz Lingens, Karl-Heinz van Pée
      Pages 129-136
    6. J. Novotná, J. Neužil, I. Vančurová, V. Běhal, Z. Hošt’álek
      Pages 137-143
    7. A. V. Orekhov, S. B. Zotchev, G. Y. Florova, A. R. Foors, L. B. Gul’ko, S. M. Rosenfeld et al.
      Pages 145-152
  4. Antibiotic Resistance

    1. Wolfgang Piepersberg
      Pages 153-159
    2. Wolfgang Piepersberg, Peter Heinzel, Kambiz Mansouri, Ulrike Mönnighoff, Klaus Pissowotzki
      Pages 161-170
    3. Wolfgang Wohlleben, Walter Arnold, Iris Behrmann, Inge Broer, Doris Hillemann, Alfred Pühler et al.
      Pages 171-183
    4. Hans Krugel, Gisela Fiedler, Frank Hanel, Colin Smith, S. Baumberg
      Pages 185-193
    5. Hiroshi Ogawara
      Pages 195-202
  5. Protein Secretion

    1. Dieter Kluepfel
      Pages 203-205
    2. Dieter Kluepfel, Rolf Morosoli, François Shareck
      Pages 207-214
    3. Klaus-P. Koller, Günther Rieß, Klaus Sauber, László Vértesy, Eugen Uhlmann, Holger Wallmeier
      Pages 227-233
    4. Claudine Piron-Fraipont, Mauro V. Lenzini, Jean Dusart
      Pages 235-241
  6. Genetic Instability

    1. H. Schrempf
      Pages 243-243
    2. H. Schrempf
      Pages 245-252
    3. Josef Altenbuchner, Christa Eichenseer
      Pages 253-263
    4. John Cullum, Fiona Flett, Birgit Gravius, Daslav Hranueli, Kiyotaka Miyashita, Jasenka Pigac et al.
      Pages 265-272
  7. Instabilities and Population Genetics

  8. Back Matter
    Pages 327-328

About this book


The Streptomycetes are industrially widely used microorganisms due to their ability to produce numerous different chemical compounds. These show very varied effects upon other living systems, and result from profound and subtle biochemical and morphological differentiation during the streptomycete life cycle. It is therefore not surprising that research on the genetics of antibiotic biosynthesis and differentiation in this group is currently progressing rapidly in many countries. Intimately connected with the production of antibiotics is resistance to them; analysis of this is giving further information about the origin and evolution of this class of genes and their hypothesized spread among other microorganisms. Another interesting feature of the Streptomyces group is their mycelial growth. Also, their ecologically important utilization of high molecular weight compounds requires enzymes to be transported outside the cell to hydrolyze non-diffusible substrates. Finally, we have as yet limited understanding of the various mechanisms of genome rearrangement observed in some of these species; deletions and/or amplifications of enormous amounts of DNA can occur without seriously affecting the viability of the organism under laboratory conditions. The present volume, which includes contributions addressing the above subjects and others, originates from a meeting on "Genetics and Product Formation in Streptomyces" sponsored by the Federation of European Microbiological Societies in Erfurt on May 1-6 1990. Compared to previous ones of this kind held in 1979, 1983 and 1987 in Weimar, one can point to impressive progress in the study and applications of Streptomyces genetics.


DNA enzymes genes genetics transport

Editors and affiliations

  • Simon Baumberg
    • 1
  • Hans Krügel
    • 2
  • Dieter Noack
    • 2
  1. 1.University of LeedsLeedsUK
  2. 2.Institut für Mikrobiologie und Experimentelle TherapieJenaGermany

Bibliographic information